The Role of Pregnenolone in Inflammatory Degenerative Brain Disease | OMICS International | Abstract
ISSN: 2381-8727

International Journal of Inflammation, Cancer and Integrative Therapy
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Review Article

The Role of Pregnenolone in Inflammatory Degenerative Brain Disease

Ferri C1 and Fioranelli M1,2*

1Marconi University, Rome, Italy

2University B.I.S. Group of institutions, Punjab Technical University, Punjab, India

*Corresponding Author:
Massimo Fioranelli
Professor, Marconi University
Rome, Italy
Tel: +61 74 9232008
E-mail:[email protected]

Received date: November 23, 2014; Accepted date: December 04, 2014; Published date: December 06, 2014

Citation: Ferri C and Fioranelli M (2014) The Role of Pregnenolone in Inflammatory Degenerative Brain Disease. Interdiscip J Microinflammation 1:121. doi: 10.4172/2381-8727.1000121

Copyright: © 2014, Fioranelli M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Pregnenolone is a steroid hormon that is directly produced by the brain as well, that is why it is defined neurosteroid. Pregnenolone carries out several cerebral functions, such as neuroprotection, neuroplasticity and neurogenesis; moreover, it regulates the mood and the memory. All of these functions are possible thanks to the relationships pregnenolone establishes with some of the most important neurotransmitters. As a matter of fact, it connects to GABA receptors, NMDA receptors and sigma-1 receptors. It has been proved that pregnenolone is concerned with some important neurological and psychiatric diseases. Actually, some scientists hypothesize that it could also be useful to these diseases' pharmacotherapy. This article illustrates the ways pregnenolone may be used and the ways it is concerned with neurological and neuropsychiatric diseases.