Antimicrobial Efficacy Of Achyranthes Aspera (Linn.), A Terrestrial Weed | 2486
Journal of Earth Science & Climatic Change
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ndia is a land of rich biodiversity and plants are the potential source of medicines since ancient times. Achyranthes aspera Linn.
(Amaranthaceae) is commonly found as a terrestrial weed on waysides and waste places throughout India. In ayurvedic system
of medicine, the parts of this plant are used to treat various types of chronic as well as infectious diseases. Crude organic (ethanol,
methanol and acetone) and aqueous (hot and cold) extracts from A. aspera leaves and roots were tested against five bacterial
(Staphylococcus aureus, Proteus mirabilis, Escherchia coli, Pseudomonas aeruginosa, Acinetobacter sp) and one fungal (Candida
albicans) ear pathogen through agar well diffusion method. Organic leaves and root extracts of this plant were found active against
three bacteria: S. aureus, P. mirabilis and E. coli with zone of inhibition ranging between 13.6 mm and 22.6 mm while aqueous leaves
extracts (hot and cold) displayed activity against two pathogens (S. aureus and P. mirabilis) and aqueous root extract showed activity
against one pathogen, S. aureus with zone of inhibition ranging between 18.3 mm and 13.6 mm. Of the bacterial pathogens tested,
S.aureus was found most sensitive with maximum zone of inhibition of 22.6mm and 18.6mm followed by P.mirabilis (21.6mm and
17.3mm) and E. coli (16.3mm and15.6 mm). The zone of inhibition shown by the six organic extracts, both leaves and roots, against
C.albicans was weak that ranged between 13.6 mm and 16.3 mm. The aqueous extracts totally lacked antiyeast activity. The MIC
value for A. aspera leaves and roots extracts ranged between 12.5mg/ml and 50mg/ml. S.aureus and P.mirabilis were found more
sensitive pathogens showing the lowest MIC of 12.5mg/ml and 25mg/ml in ethanolic extracts whereas E.coli was found least sensitive
with MIC of 50mg/ml. MIC value for C.albicans in all the organic extracts was 50mg/ml. Ethanolic extracts of both leaves and roots
of A. aspera were found best among all the tested solvents followed by acetonic, methanolic, hot aqueous and cold aqueous extract.
Keeping in view the good antimicrobial activity of weeds against human pathogens, this weed should be protected for its exploitation
as an antimicrobial agent in pharmaceutical industry for the welfare of human beings. However, more detailed studies such as in vivo
testing of this weed to determine its toxicity and pharmacokinetics properties are needed to determine their therapeutic potential.
Dr. Chetan Sharma has done his PhD. in Microbiology with the Professor K.R. Aneja from Kurukshetra University, Haryana, India (2012). His primary
field is medical, herbal and environmental microbiology with research emphasis on antimicrobial potential of plants and chemical compounds
against the human pathogens. Presently, he is working as Assistant Professor in Department of Microbiology, Kurukshetra University, India. He has
published more than 40 research papers in reputed journals and screened about 60 plants against the ear pathogens. He also serves as Regional
Editor of five journals of Science alert, USA and as reviewer for Microbiology Research journal published by Bio info publications. He is also member
of editorial board in International Journal of Pharmacy and Pharmaceutical Sciences, India
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