Clinical Pharmacology & Biopharmaceutics
Open Access

Abstract

As a result of their significant biological potential β-amino acids exhibit an important role in medicinal and organic chemistry. Several small molecular entities of this class of derivatives, such as cispentacin, icofungipen, oryzoxymycin or oxetin possess relevant antifungal or antibacterial properties. Apart from the importance of fluorinated biomolecules or fluorine-containing drugs, several fluorinated α and acyclic β-amino acids are known as anti-tumoral agents or antibiotics. Stereo and regioselective synthetic protocols has been accomplished towards the access of various highly functionalized fluorinated β-amino acid derivatives and fluorinated heterocyclic scaffolds, involving stereoselective functionalization by epoxidation or aziridination of some unsaturated bicyclic β-lactams as model compounds followed by regioselective heterocycle ring opening and fluorination with Deoxofluor or Xtal-Fluor reagents.

Biography

Lorand Kiss has completed his PhD in 2002 from the Department of Organic Chemistry at Debrecen University, Debrecen, Hungary under the supervision of Professor Sandor Antus. In 2003, he has joined the research group of Professor Ferenc Fulop at the Institute of Pharmaceutical Chemistry, University of Szeged, Hungary, where he started to work in the field of cyclic β-amino acid chemistry. He has completed his Postdoctoral studies in the laboratories of Professor Norbert De Kimpe at Ghent University, Belgium and Professor Santos Fustero at the Department of Organic Chemistry, University of Valencia, Spain. He has published 68 scientific papers in reputed journals (cumulative IF 225.93). He is currently a faculty Member at the Institute of Pharmaceutical Chemistry, University of Szeged. His scientific interest is directed towards the selective functionalization of alicyclic and heterocyclic β-amino acids, synthesis of highly functionalized fluorinated building blocks.

Email: kiss.lorand@pharm.u-szeged.hu