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Hindi Research Article
Naturally Occurring Enzyme Inhibitors: A Smart Way to Fight against Micro- Inflammation in Human Gut
Rabail Razi1, Zainab Mir1, Rimsha Dilshad1, Fatima Tuz Zahra1 and Atif AB2*1Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan
2Molecular Medicine, Biomedical Center, Faculty of Medicine, Universiti Sultan Zainal Abidin, Malaysia
- *Corresponding Author:
- Atif AB
Faculty of Medicine
Universiti Sultan Zainal Abidin
Tel: +6096275587
E-mail: atifamin@unisza.edu.my
Received date: February 05, 2015; Accepted date: June 28, 2015; Published date: June 30, 2015
Citation: Razi R, Mir Z, Dilshad R, Zahra FT, Atif AB (2015) Naturally Occurring Enzyme Inhibitors: A Smart Way to Fight against Micro-Inflammation in Human Gut. Interdiscip J Microinflammation 3:131. doi: 10.4172/2381-8727.1000131
Copyright: © 2015 Razi R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Human body is a reservoir for microorganisms, the majority of which resides in the gastrointestinal tract. The diverse micro biota helps to speed up the metabolic processes such as digestion along with providing protection against infections. A balanced diet plays major role in maintaining the balance of gut flora, which could otherwise lead to Dysbiosis. Dysbiosis is an inflammatory condition caused by the over production of bacterial nitroreductase, azoreductase and beta-glucuronidase enzymes. In the following article the active sites of all three enzymes along with their inhibitors were studied. One inhibitor against nitroreuctase, two against azoreductase and three against beta-glucuronidase were selected and docking was done. The inhibitors blocked the enzymes activity. These inhibitors can be obtained from natural food sources to attain a balanced microbial flora resulting in a better metabolism.
