alexa Abstract | Rifampicin-Resistance Tuberculous Meningitis in a Patient with Cerebral Lupus Diagnosed Using Cerebrospinal Xpert Mtb/Rif Test
E-ISSN: 2314-7326
P-ISSN: 2314-7334

Journal of Neuroinfectious Diseases
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Case Report Open Access

Abstract

Tuberculous (TB) meningitis or tubercular meningitis is a Mycobacterium tuberculosis infection of the meninges—the system of membranes which envelop the central nervous system. Molecular tests like the automated rapid molecular assay Xpert® MTB/RIF greatly expedites the detection of M. tuberculosis complex and rifampicin resistance. We report a 22-year old man with cerebral lupus and concurrent rifampicin resistance tuberculous meningitis which was detected by Xpert® MTB/RIF test in the cerebrospinal fluid. The rifampicin resistance in this patient was due to poor compliance. The patient took one tablet of akurit-4 throughout the intensive phase of treatment. This report highlights the usefulness of molecular testing which allowed a faster diagnosis than a bacteriologic confirmation of drug resistant tuberculosis. This is important as early diagnosis and treatment leads to better outcome in TBM.

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Author(s): Mohamed Faisal Abdul Hamid, Soo Chun Ian, Andrea Ban Yu-Lin, Mohd Shahrir Mohamed Said and Roslina Abdul Manap

Keywords

Nervous System, Viral Infection, Fungal Infection, Neuroinfectious Agents, Non-Polio Enterovirus Infections, Opisthorchis Infection,Sinus Infections,Central nervous system vasculitis,Central nervous system vasculitis

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