Journal of Clinical & Experimental Pathology
Open Access

Santo V. Nicosia

Biography

Santo V. Nicosia is currently working as a Professor. The author's research interests include Clinical Pathology, Histopathology, Hemato Pathology, Surgical Pathology, Diagnosis. The author is serving as an editorial member and reviewer of several international reputed journals. The author has successfully completed his Administrative responsibilities. The author has authorized many research articles/books related to Clinical Pathology, Experimental Pathology.

Research Interest

Clinical Research: Recent trends toward conservative surgery for breast cancer and increasing detection of smaller invasive malignancies have shifted the traditional surgical approach from mastectomy to lumpectomy and from complete axillary lymph node dissection to sentinel lymph node biopsy in order to avoid extensive procedures in node-negative women. In collaboration with Dr. Charles Cox, we have developed imprint cytology procedures for the intraoperative analysis of lumpectomy margins and sentinel lymph nodes that allow for a rapid analysis of residual and metastatic disease in breast cancer patients without loss of diagnostic tissue and artifacts associated with pathological evaluation by the traditional frozen section method. Basic research: This research focuses on the mechanisms that regulate the development of the most lethal gynecologic malignancy, epithelial ovarian cancer. In particular, our laboratory is interested in genes and gene products involved in the morphogenesis of serous papillary neoplasms. Using DNA microarray analysis, tissue morphogens such as FGF18, ephrins, Hox B7 and BMP7 have been identified. As a member of an International Consortium on early ovarian cancer detection, our group is also investigating the contribution of Fallopian tubes to epithelial ovarian carcinogenesis in high risk women. Translational research: We have previously shown that vascular endothelial growth factor (VEGF) stimulates ovarian epithelial morphogenesis and plays an important role in ovarian cancer related-angiogenesis and tumor progression. Translating these results to the bedside, our laboratory has evaluated the expression of angiogenic (VEGF and hepatocyte growth factor) and angiostatic (angiostatin and endostatin) factors in women with benign and malignant ovarian lesions and shown that seriousness of clinical status correlates best with urinary levels of angiostatin. The utility of urinary angiostatin as a biomarker of early epithelial ovarian cancer and cancer progression is now under investigation in a large cohort of women.

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