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Dr. Simone Duarte is Assistant Professor in the Department of Basic Science and Craniofacial Biology and the course director of Pharmacology at the College of Dentistry. Dr. Duarte’s research focuses on the understanding and control of cariogenic dental biofilms using natural agents. She is working together with Dr. David Grier, from the department of Physics and Center for Soft Matter Reseach at New York University, trying to establish a new methodology to analyze the physical properties of dental biofilms, using holographic microrheology. This new methodology is very unique and shows promise for high-throughput combinatorial screening of candidate therapeutic or remedial agents. In addition, Dr. Duarte’s lab also studies the structural characterization of the biofilm matrix, using Confocal Laser Scanning Microscopy (CLSM); quantifying the structural properties by analyzing the CLSM images using COMSTAT software (Heydorn et al., 2000). Rather than assessing their biological or biochemical influence, holographic microrheology together with CLSM offers direct insight into these agents influence on biofilm matrix’s structure and physical properties.
Biofilm matrix - structural and physical properties
Effect of Microgravity on microbial biofilms
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