alexa Han Koh | OMICS International
ISSN: 2167-065X

Clinical Pharmacology & Biopharmaceutics
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Han Koh


L-Glutamine Therapy Reduces Hospitalization for Sickle Cell Anemia and Sickle β°-Thalassemia Patients at Six Months – A Phase II Randomized Trial

Background: Increased oxidant stress plays an important role in the pathophysiology of sickle cell disease. Nicotinamide Adenine Dinucleotide (NAD) is an important anti-oxidant that protects hemoglobin as demonstrated in diseases such as methemoglobinemia. Early in-vitro studies have shown that L-glutamine, a precursor for NAD, reduced oxidant stre... Read More»

Yutaka Niihara, Henry Macan, James R. Eckman, Han Koh, Melanie L Cooper, Thomas R Ziegler, Rafael Razon, Kouichi R Tanaka, Charles W Stark and Cage S Johnson

Research Article: Clin Pharmacol Biopharm 2014, 3:116

DOI: 10.4172/2167-065X.1000116

Abstract Peer-reviewed Full Article Peer-reviewed Article PDF