Clinical Pharmacology & Biopharmaceutics
Open Access

Thomas R Ziegler

Grady Medical Center Atlanta GA, USA

Biography

Thomas R. Ziegler, MD is physician-scientist with significant experience in clinical and translational research (CTR), including mentoring, leading randomized clinical trials, and administration of research centers and training programs. His nutrition-oriented CTR, which focuses on nutritional support strategies and metabolomics in catabolic states such as malnutrition, critical illness, and infection (e.g. HIV, TB) is internationally recognized. He been continuously funded by NIH since 1996 by M01, R01, U01, R21, R03, P30, K24, and UG3 mechanisms and has published more than 172 original manuscripts.

Publications

L-Glutamine Therapy Reduces Hospitalization for Sickle Cell Anemia and Sickle β°-Thalassemia Patients at Six Months – A Phase II Randomized Trial

Background: Increased oxidant stress plays an important role in the pathophysiology of sickle cell disease. Nicotinamide Adenine Dinucleotide (NAD) is an important anti-oxidant that protects hemoglobin as demonstrated in diseases such as methemoglobinemia. Early in-vitro studies have shown that L-glutamine, a precursor for NAD, reduced oxidant stre... Read More»

Yutaka Niihara, Henry Macan, James R. Eckman, Han Koh, Melanie L Cooper, Thomas R Ziegler, Rafael Razon, Kouichi R Tanaka, Charles W Stark and Cage S Johnson

Research Article: Clin Pharmacol Biopharm 2014, 3:116

DOI: 10.4172/2167-065X.1000116

Abstract Peer-reviewed Full Article Peer-reviewed Article PDF