alexa Editor - Fei Li | Laboratory of Metabolism National Cancer Insti | 10257
ISSN: 2157-7609

Journal of Drug Metabolism & Toxicology
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Fei Li

Fei Li Fei Li
Laboratory of Metabolism
National Cancer Institute
National Institutes of Health
USA
Tel: 301-402-2499
Fax: 301-496-8419
Biography

Dr. Fei Li is currently working as Visiting Fellow, Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, USA.

Research Interest

Metabolism, toxicity, and carcinogenicity of drugs and chemicals: Cytochromes P450 (P450) involve in metabolism of drugs and chemicals in vivo, and catalyze the inactivation or metabolic-activation of chemical carcinogens. A multi-faceted approach, including mouse model, molecular biology, and analytical chemistry is used to investigate the roles of metabolism enzymes in toxicity and
carcinogenicity. I have focused on the study of the toxicity of several drugs, including ifosfamide, cyclophophamide, thioTEPA, and procainamide, and the effect of CYP1B1 on benzo[α]pyrene using CYP1B1-null and humanized mice. Part of results has been published on Biochemical Pharmacology and British Journal of Pharmacology.
• Metabolic profiling of drug efficacy and toxicity: Xenobiotic receptors, such as peroxisome proliferator activated receptor (PPAR) and farnesoid X receptor (FXR), can mediate the metabolic response of organism to the chemical environment. However, in many cases, activation of xenobiotic receptors can
lead to toxic and carcinogenic responses. The transgenic mice, including knockout and humanized mice, can be used to study the mechanism of drug efficacy and toxicity. I have worked on the effect of
PPARα and FXR on drug efficacy and toxicity. Part of results has been published in Journal of Lipid Research and Journal of Proteome Research.
• Identification of biomarkers for diseases using mass spectrometry based-metabolomics: Metabolomics using liquid and gas chromatography linked to mass spectrometers (UPLC-QTOFMS and GC-MS) as analytical platforms, is being actively used to systematically identify and quantify all metabolites in a
given organism or biological sample. The small molecule biomarkers of diseases are identified through the targeted- and untargeted-metabolomic analysis of metabolites in serum, urine and tissue homogenate. Some endogenous biomarkers of several diseases, including cancer, diabetes, liver cholestasis, and glaucoma, have been identified in my research using this technology. Part of results has been published in Journal of Biological Chemistry.

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Publications

Radiation Sensitization of Keloid Firboblasts by Quercetin through PI3K/Akt Pathway Dependent Regulation of HIF-1α
Loubin Si, Qin Han, Xiao Long, Fei Long, Robert Chunhua Zhao, Jiuzhuo Huang, Zhifei Liu, Ru Zhao, Hailin Zhang, Xiaojun Wang
Research Article: J Clin Exp Dermatol Res 2017, 8: 409
DOI: 10.4172/2155-9554.1000409
 
Resveratrol Inhibits Proliferation and Promotes Apoptosis of Keloid Fibroblasts by Targeting HIF-1α
Loubin Si, Qin Han, Xiao Long, Fei Long, Robert Chunhua Zhao, Jiuzhuo Huang, Zhifei Liu, Ru Zhao, Hailin Zhang and Xiaojun Wang
Research Article: J Clin Exp Dermatol Res 2017, 8: 436
DOI: 10.4172/2155-9554.1000436
 
Immunogenicity and Efficacy of Coxsackievirus A16 Vaccine Candidate Formulations in a Mouse Model
Jia Lu , Linlin Zhang , Taixue An , Qunying Mao , Pengfei Li , Fukun Zhang , Li Li , Hui Zhou , Jiling Wang , Xiaoqi Chen , Zejun Wang , Zhenglun Liang and Shuo Shen
Research Article: J Mol Immunol 2017, 2: 105
 
Evaluation of TEE Training for Chinese Anesthesiology Residents Using Two Various Simulation Systems
Fei Liu, Fu S Lin, Yong G Peng, Li Liu, Massimiliano Meineri, Hai B Song and Jin Liu
Research Article: J Anesth Clin Res
DOI: 10.4172/2155-6148.1000611
 
Giant Retrovesical Ectopic Prostate Tissue: A Case Report and Review of the Literature
Shidong L, Wanlong Tan, Chengyong Lei, Fei Li, Xiongwei Shan, Xiaoming Yu and Qiang wei
Case Report: Andrology (Los Angel), 4: 135
 
The Influence on Livestock Industry and Development Prospect of Eupatorium adenophorum Spreng
Fei Liao, Yanchun Hu, Yue Huang, Xi Liu, Hui Tan, Yunfei Wang, Quan Mo, Zhongrong Jiang and Shijin Deng
Research Article: J Microb Biochem Technol 7: 057-060
DOI: 10.4172/1948-5948.1000182
 
Reliability and Validity of a Parent-Assessed Impulsiveness Scale for Chinese Children
Fei Li, Lin-Yan Su* and Yao-Guo Geng
Research Article: J Psychiatry
DOI: 10.4172/Psychiatry.1000230
 
Altered Expression and DNA Methylation Profiles of ERCC6 Gene in Lens Tissue from Age-Related Cortical Cataract
Yong Wang , Guowei Zhang , Fei Li , Lihua Kang , Jindong Ben , Han Rong and Huaijin Guan
Research Article: J Clin Exp Ophthalmol 2015, 6: 392
DOI: 10.4172/2155-9570.1000392
 
Combined SVM-PLS Method for Predicting Estrogenic Activities of Organic Chemicals in the Coastal water
Fei Li, Lulu Cao, Huifeng Wu, Jianmin Zhao
Research Article: J Coast Dev
 
Aromatic lichen resources in Guizhou Province, China
Bo Liu, Yujing Liu, Jianqin Li, Ronghui Gu, Wujisiguleng, Ping Li and Feifei Li
Research Article: Med Aromat Plants 2014, 3: 146
DOI: 10.4172/2167-0412.1000146
 
Characterization of Fe2O3/FeOOH Catalyzed Solvolytic Liquefaction of Oil Palm Empty Fruit Bunch (EFB) Products
Sarani Zakaria, Tze Khong Liew, Chin Hua Chia, Fei Ling Pua, Fan Suet Pin, Rasidi Roslan, Umar Adli Amran, Antje Potthast, Thomas Rosenau and Falk Liebner
Special Issue Article: J Bioremed Biodeg 2013, S4-001
DOI: 10.4172/2155-6199.S4-001
 
Metabolomics: One Powerful Tool for the Understanding of Xenobiotic Receptors
Fei Li
Editorial: J Chromat Separation Techniq 2012, 3:e107
DOI: 10.4172/2157-7064.1000e107
 
Xenobiotic Metabolomics: An Ideal Tool for Drug Metabolism
Fei Li
Editorial: J Chromat Separation Techniq 2012, 3:e106
DOI: 10.4172/2157-7064.1000e106
 
Aging: The Mitochondrial Connection
Katharine Brown, Yufei Liu, and Danica Chen
Special Issue Article: J Clin Exp Pathol S4: 003
DOI: 10.4172/2161-0681.S4-003
 
Road Map to Drug Discovery and Development - Inhibiting C-reactive protein for the Treatment of Cardiovascular Disease
Jan Torzewski, Kefei Li and Oliver Zimmermann
Review Article: JBB/Volume S1: 001, Special Issue 2011
DOI: 10.4172/jbb.S1-001
 
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