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In the past, my studies have focused on inflammatory mechanisms associated with nephritogenic poststreptococcal toxins and with other models of immune renal disease. Currently, I am evaluating the role of the enzyme arginase in vascular dysfunction associated with coronary heart disease and nephropathy in murine models of diabetes as well as in angiotensin II-infused hypertensive animal models. Since arginase is a key component of the hepatic urea cycle, and has other important contributions in cellular metabolism, my major interest is to decipher the mechanisms leading to upregulation of arginase and to determine the short and long term effects of arginase inhibition on diabetic organ dysfunction.
Enzymology, Diabaetis, Arginase
|Maritza J. Romero and William Caldwell R|
|Editorial: J Autacoids 2012, 1:e115|