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Dr. Pradeep K. Karla is an Assistant Professor in Pharmaceutical Sciences at Howard University, School of Pharmacy. The significance of Dr. Karla’s research involves the discovery of new drug efflux transporters on human ocular tissue, Cornea, which forms the primary barrier for topical ocular drug delivery. Dr. Karla’s research have demonstrated for the first time that these transporters play a vital role in decreased ocular bioavailability of drugs employed in chronic disease states such as glaucoma and ocular herpes. In-vivo ocular microdialysis studies in rabbit animal model have demonstrated promising results, where ocular bioavailability improved significantly with modulation of the transporters.
Dr. Karla is interested in implementing new technologies to promote active learning in classroom. Dr. Karla’s research in teaching method development involves integrating tablet touch interface of faculty and student tablet PC’s via Wi-Fi network to create a real time interactive platform.Current research in our laboratory involves the screening of wide array of ocular drugs for substrate specificity of the multiple drug efflux transporters identified and testing of nano-ophthalmic/pro-drug strategies as drug delivery options for improved bioavailability. The long-term goal would be to develop an efficient ophthalmic drug delivery strategy for improved ocular bioavailability of drugs administered topically.
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