alexa Rafik Karaman | Al-Quds University
ISSN: 2469-9764

Industrial Chemistry
Open Access

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Rafik Karaman

Rafik Karaman Rafik Karaman
College of Pharmacy
Al-Quds University
Jerusalem
Israel
Biography

Professor Rafik Karaman is currently a distinguished professor of pharmaceutical sciences, College of Pharmacy, Al-Quds University, Jerusalem, Palestine. He received his Ph.D. degree in pharmaceutical/bioorganic chemistry from the Hebrew University in 1987, his MS degree in Pharmaceutical Sciences from the Hebrew University in 1983, and his bachelor’s degree in Pharmacy from the Hebrew University in 1981. He was an Assistant Professor at the University of Toledo and University of California at Santa Barbara for 5 years where he worked with Professor T.C.Bruice in the bioorganic chemistry field. Professor Karaman is broadly interested in the design and synthesis of prodrug systems to be used for the delivery of certain drugs that have poor water solubility or/and have low bioavailability as well as synthesis of prodrugs for masking the bitter sensation of commonly used drugs. The prodrug design is executed using ab initio, DFT, semiempirical, molecular mechanics as well as molecular dynamics and conformational dynamics methods. The overarching goal of Karaman’s research activities is to establish a method for obtaining prodrugs that their interconversion rates will be controlled or programmed by the chemical features of the linker (promoiety) attached to their active parent drugs. Professor Karaman has more than 150 peer-reviewed manuscripts and book chapters; 100 of them were published in the recent 7 years.

Research Interest

Design, synthesis, characterization and in vitro and in vivo kinetics of pro-prodrug systems to be used for the delivery for certain drugs, Design and synthesis of linkers to be used for masking bitter taste of drugs that contain a hydroxyl or amine groups, Design and synthesis of bitter taste antagonists for inactivation of the bitter taste receptor 14.The design will be accomplished using molecular orbital and molecular mechanics methods, Pharmaceuticals removal from wastewater using clay micelle complex, hollow fiber, spiral wounds, charcoal and other adsorbents, Pharmaceuticals removal from wastewater using photodegradation methods such as light/TiO2, Stability of Pharmaceuticals in wastewater and isolation and characterization of degradation products (metabolites).

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Publications

A Solution to Aversive Tasting Drugs for Pediatric and Geriatric Patients
Rafik Karaman
Editorial: Drug Des 2013, 2: e116
DOI: 10.4172/2169-0138.1000e116
 
The Prodrug Naming Dilemma
Rafik Karaman
Editorial: Drug Des 2013, 2: e115
DOI: 10.4172/2169-0138.1000e115
 
Prodrug Design vs. Drug Design
Rafik Karaman
Editorial: Drug Des 2013, 2: e114
DOI: 10.4172/2169-0138.1000e114
 
Prodrug Design by Computation Methods: A New Era
Rafik Karaman
Editorial: Drug Des 2012, 2: e113
DOI: 10.4172/2169-0138.1000e113
 
Computationally Designed Enzyme Models To Replace Natural Enzymes In Prodrug Approaches
Rafik Karaman
Editorial: Drug Des 2012, 2: e111
DOI: 10.4172/2169-0138.1000e111
 
Computationally Designed Prodrugs for Masking the Bitter Taste of Drugs
Rafik Karaman
Editorial: Drug Des 2012, 2: e106
DOI: 10.4172/2169-0138.1000e106
 
Validated HPLC Method to Simultaneously Determine Amprolium Hydrochloride, Sulfaquinoxaline Sodium and Vitamin K3 in A.S.K Powder on ZIC-HILIC Column
Mashhour Ghanem, Saleh Abu-Lafi, Rafik Karaman and Hussein Hallak
Research Article: Pharm Anal Acta 2012; 3:168
DOI: 10.4172/2153-2435.1000168
 
The Future of Prodrugs Designed by Computational Chemistry
Rafik Karaman
Editorial: Drug Design 2012, 1: e103
DOI: 10.4172/2169-0138.1000e103
 
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