alexa HMGB1-TLR Signaling in Rasmussens Encephalitis
E-ISSN: 2314-7326
P-ISSN: 2314-7334

Journal of Neuroinfectious Diseases
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Review Article

HMGB1-TLR Signaling in Rasmussens Encephalitis

Tianfu Li1,3,4,*, Qing Gao3 and Guoming Luan2,3,4

1Department of Neurology, Beijing Sanbo Brain Hospital, Capital Medical University, Beijing, China

2Department of Neurosurgery, Beijing Sanbo Brain Hospital, Capital Medical University, Beijing, China

3Beijing Key labartory of Epilepsy, Beijing, China

4Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing, China

*Corresponding Author:
Tianfu Li
Professor and Chief Physician, Department of Neurology
Beijing Sanbo Brain Hospital, Capital Medical University
Xiangshan Yikesong 50, Haidian district
Beijing, 100093, P.R. China
Tel: +86 1062856761
Fax: +86-10-62856902
E-mail: [email protected]

Received date: July 25, 2016; Accepted date: August 09, 2016; Published date: August 12, 2016

Citation: Li T, Gao Q, Luan G (2016) HMGB1-TLR Signaling in Rasmussens’ Encephalitis. J Neuroinfect Dis 7: 223. doi: 10.4172/2314-7326.1000223

Copyright: © 2016 Li T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Rasmussen’s encephalitis is neurological disorder of childhood characterized by uni-hemispheric inflammation, intractable focal epilepsy and progressive cognitive and neurological deficits. Currently, the pathogenesis of Rasmussen’s encephalitis is still enigmatic and hemispherectomy is the only effective method to control the seizures associated with Rasmussen’s encephalitis. Recently data indicated that intrinsic activation of endogenous proinflammation high-mobility group box-1 (HMGB1) and Toll-like receptor (TLR) is involved in the development of Rasmussen’s encephalitis. Activation of HMGB1-TLR signaling plays a critical role in brain inflammation, development of epilepsy and cognitive dysfunction. Targeted therapy on HMGB1-TLR signaling might be a novel strategy with anti-inflammation, anti-epilepsy as well as improving cognitive dysfunction associated with epilepsy in Rasmussen’s encephalitis.

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