alexa Investigation of the Diagnostic Performance of Dimethyl Arginine Derivate and Lisosomal Enzymes in Patients with Rheumatoid Arthritis
ISSN: 2381-8727

International Journal of Inflammation, Cancer and Integrative Therapy
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Research Article

Investigation of the Diagnostic Performance of Dimethyl Arginine Derivate and Lisosomal Enzymes in Patients with Rheumatoid Arthritis

Spasovski D1*, Alabakovska S2, Jankulovski N3, Bozinovski G1, Bogdanovska S4, Grcevska L4, Sotirova T5, Genadieva-Stavric S5, Chaparovska D6, Gjorcev A7 and Sadicario S8

1Department of Rheumatology, University Clinical Centre, Skopje, Republic of Macedonia, Roman, Italy

2Instituts of Preclinical biochemistry, University Clinical Centre, Skopje, Republic of Macedonia, Roman, Italy

3Department of Digestive Churgery, University Clinical Centre, Skopje, Republic of Macedonia, Roman, Italy

4Department of Nephrology, University Clinical Centre, Skopje, Republic of Macedonia, Roman, Italy

5Department of Hematology, University Clinical Centre, Skopje, Republic of Macedonia, Roman, Italy

6Department of Toxicology, University Clinical Centre, Skopje, Republic of Macedonia, Roman, Italy

7Department of Pulmology, University Clinical Centre, Skopje, Republic of Macedonia, Roman, Italy

8Department of Cardiology, University Clinical Centre, Skopje, Republic of Macedonia, Roman, Italy

*Corresponding Author:
Dejan Spasovski
Department of Rheumatology, University Clinical Centre
Skopje, Republic of Macedonia, Rome, Italy
Tel: +389023147147
E-mail: [email protected]

Received date: September 29, 2014; Accepted date: October 20, 2014; Published date: October 22, 2014

Citation: Spasovski D, Alabakovska S, Jankulovski N, Bozinovski G, Bogdanovska S, et al. (2014) Investigation of the Diagnostic Performance of Dimethyl Arginine Derivate and Lisosomal Enzymes in Patients with Rheumatoid Arthritis. Interdiscip J Microinflammation 1:119. doi: 10.4172/2381-8727.1000119

Copyright: © 2014, Grazia RM et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Introduction: Untreated Rheumatoid Arthritis (RA) has implications on renal tissue as one of the visceral manifestations of disease. Arthritis primarily damages the proximal renal tubules.

Aim: To compare the diagnostic values of laboratory variables; to find the predictive value of the positive and negative test and accuracy of the tests for Symmetric Dimethyl Arginine (SDMA), N-acetyl-β-D-glucosaminidase (NAG), microalbuminuria, rheumatoid factor (RF), C-reactive protein (CRP) andDisease Activity Score 28 index (DAS 28); and to detect the effect of untreated rheumatoid arthritis on glomerular and tubular function.

Patients and methods: Quantification of N-acetyl-β-D-glucosaminidase is used for colorimetric assay, ELISA method for detection of SDMA, immunoturbidimetry assay for microalbuminuria and agglutination test for RF. Serum and urine simples are examined in 70 participants (35 patients with untreated rheumatoid arthritis and 35 healthy individuals as control group).

Results: Of 35 examined patients with RA, we found presence of NAG enzymuria (sensitivity of the test; 37.14%) in 13, while microalbuminuria appeared in 4 patients (sensitivity of the test; 11.42%). SDMA was present in 26 patients (sensitivity of the test; 74.58%), while RF was detected in 17 patients (sensitivity of the test; 48.57%).

Conclusion: SDMA and NAG have higher sensitivity than microalbuminuria in the detection of asymptomatic renal impairment in untreated RA.

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