An Alternative Grading System For Ototoxicity In Adults: Towards A Uniform International Standard For Grading Ototoxicity | 43331
Otolaryngology: Open Access
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Ototoxicity, defined as a functional impairment and cellular degeneration of the tissues of the inner ear caused by therapeutic
agents, is a common adverse event reported following treatment with various compounds such as aminoglycosides and platinum
derivatives. Ototoxicity often leads to permanent damage to cochlear and vestibular end organs and may lead to permanent hearing
loss. Several criteria have been developed over the years to document ototoxicity-induced hearing loss following treatment with
ototoxic medication. However, most of existing criteria have limitations that preclude their use across different contexts; lack of a
‘common language’ used to grade ototoxicity, do not strongly relate to functional outcomes and do not appreciate the effect of ultrahigh
frequency hearing loss. We therefore developed an alternative and more clinically relevant grading system (UCT ototoxicity
grading scale) for ototoxicity in adults that could be used across patient populations and institutions. In this study, we assessed the
feasibility of using this alternative ototoxicity grading criteria as well as compared it to existing ototoxicity grading criteria for adults.
The findings of our study showed that the new criteria was easy to use (good interrater reliability, Kappa = 0.87) and showed good
agreement with existing ototoxicity grading criteria for adults (UCT versus CTCAEv4, 73.4%; UCT versus TUNE, 78.2%). Given that
the UCT ototoxicity grading scale was developed from universally used hearing loss classification systems and it is easy to use, we
recommend it for use across different contexts and population groups.
Lebogang Ramma completed his Doctor of Audiology (AuD) degree from the University of Florida, Gainesville, USA and Master of Public Health degree (MPH) from the University of Witwatersrand, Johannesburg, South Africa. He is the current Head of Division, Division of Communication Sciences & Disorders at the University of Cape Town. He has published over 20 papers in reputed journals. He also chaired a Health Professions Council of South Africa’s task team that developed guidelines for monitoring ototoxicity in patients who are on treatment that involves ototoxic medications.