Reach Us +1-947-333-4405


An Unusual Case Of Gynecomastia And Urothelial Bladder Cancer | 78634
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Google scholar citation report
Citations : 1174

Journal of Clinical & Experimental Pathology received 1174 citations as per google scholar report

Journal of Clinical & Experimental Pathology peer review process verified at publons
Indexed In
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Open J Gate
  • Genamics JournalSeek
  • JournalTOCs
  • Ulrich's Periodicals Directory
  • RefSeek
  • Hamdard University
  • OCLC- WorldCat
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
Share This Page

An unusual case of Gynecomastia and Urothelial Bladder Cancer

13th European Pathology Congress

Peter E Stoemmer, Anja Meyer and Thomas Pusl

Pathologie Augsburg Laboratory, Germany

ScientificTracks Abstracts: J Clin Exp Pathol

DOI: 10.4172/2161-0681-C1-037

A 29-year old patient was referred to the medical clinics of ZK Augsburg; he complained of bilateral rather indolent asymmetric enlargement of his breasts: the left mamma being larger. Few small nodal consistences in the left breast was palpated; no nipple discharges were found. Ultrasonics and mammography showed a gynecomastia without features of a malignant tumor. Anamnestically, the patient practiced bodybuilding (and denied the use of androgenic steroidal anabolics); erectile functions were normal; undescended testes were corrected by surgery in childhood., the left testis was atrophic. Hormonal studies showed testosteron in the high-normal range and his estradiol and HCG were elevated, while the gonadotropins were suppressed; normal fetoprotein. Cranial MRI and Chest-CT-Scan were normal; the bladderwall in abdominal CT thickened. Cystoscopy, performed due to painless macrohematuria showed a small unifocal papillary tumor in the bladderwall followed by transurethral resection. Histology: Multiple particles of a soft, grey focal hemorrhagic tissue together 0.5g with up to 10 layers of atypical urothelia; some preserved umbrella cells.No invasion into the muscularis. IHC: ectopic expression of HCG. Diagnosis: Papillary urothelial carcinoma of the bladder with no invasion into the lamina propria (pTa G1 cN0 cM0) In the following weeks, HCG was no longer detectable, his sex hormones returned to normal, and gynecomastia completely regressed. HCG-producing tumors of the bladder are known since 1904 (1), but these were ectopic choriocarcinomas. In our case, the tumorcells are typical urothelia with ectopic HCG-production; we assume that this is the cause of estrogen- induced proliferation of male mammary glands.

Peter Stoemmer has studied medicin at the university of Erlangen-Nuremberg, Germany and completed his MD, PhD  and  specialisation as general pathologist (including cytopathology and molecular pathology) at the age of 36 years)  from Friedrich Alexander University Erlangen; after  postdoctoral studies from Yale  University School of Medicine in the laboratory of Juan Rosai and the supervision of A.B.            
 He is the director and partner of Pathologie Augsburg, an independent Laboratory for surgical Pathology. He is senior lecturer and professor at the institute of pathology at the Friedrich Alexander university and  published more than 125 papers in journals