Anaerobic Bacteriology Of Middle Ear Aspirate Culture In The Developing World: Possible Role Of Immune-compromise In Its Etio-pathogenesis | 25703
Otolaryngology: Open Access
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Objectives: The study intends to report the profiles of anaerobic bacteria isolated and attempts to evaluate the impact of
immune-compromised status of patients on the disease.
Study Design: A cross-sectional prospective study.
Setting: ENT clinic, University of Ilorin Teaching Hospital, Nigeria; a 450-bed tertiary health facility.
Subjects: 104 consecutive consenting participants with clinical evidence of CSOM≥12 weeks.
Methods: A hospital-based study conducted over a seven (7) month period. The middle ear aspirate was obtained with the aid
of a micropipette and sent immediately for Microscopy, Culture and Sensitivity of both anaerobic and aerobic bacterial isolates.
Results: A total of 11 patients with chronically discharging ears, of the 104 studied had anaerobic bacteria cultured from
their middle ear aspirates. Age ranged from 4 to 50 years with a Male:Female ratio of 1:1.8. A total of 32 isolates (11 anaerobic
and 21 aerobic) were recovered. All anaerobic organisms were mixed and included both Peptostreptococcus and Bacteroides.
Metronidazole had 100% sensitivity to gram negative and 62.5% to gram positive anaerobic organisms tested. 5 patients
had immune-compromised states of 11 patients with anaerobic bacteria isolated in middle ear aspirates (group A), while 13
immuno-compromised patients of the remaining 93 patients with no anaerobic bacteria isolated (group B). Proportion in
group A was higher (p<0.05) than in group B.
Conclusion: Immuno-compromised state and age appear to play a key role in presence of the anaerobic organisms recovered
from the middle ear of the patients studied.
Adebola Stephen Oluwatosin completed his residency training in Otolaryngology, Head and Neck surgery at the University of Ilorin Teaching Hospital, Ilorin, Nigeria
in October, 2011 with fellowships of both West African College of Surgeons (FWACS-ORL) and National Post-Graduate Medical College of Nigeria (NPMCN) in
Otorhinolaryngology. He was Editor of the Nigeria Medical Association (Kwara State chapter), 2008 ? 2010 and has published more than 16 papers in reputable
peer-reviewed journals, some of which he also serves as a reviewer. Presently he is the Head, Department of Otorhinolaryngology, Ladoke Akintola University of
Technology (LAUTECH) Teaching Hospital, Ogbomoso, Nigeria. His research interests are in, allergy, head and neck infections, trauma and hearing loss research.
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