alexa Application Of A Microfluidic Chip-based 3D Co-culture To Test Drug Sensitivity For Individualized Treatment Of Lung Cancer
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd International Conference and Exhibition on Pathology
April 14-15, 2014 Hilton San Antonio Airport, TX, USA

Wenxin Wang
Accepted Abstracts: J Clin Exp Pathol
DOI: 10.4172/2161-0681.S1.014
Abstract
Individualized treatment is a promising clinical strategy for lung cancer, and drug sensitivity testing is fundamental to this scheme. We aimed to develop an effective drug sensitivity test platform to support individualized treatment. We designed a microfluidic chip-based, three-dimensional (3D) co-culture drug sensitivity test platform. A mono-lung cancer cell line, a mixture of lung cancer and stromal cell lines, and cells from fresh lung cancer tissues were cultured in 3D under continuous media supplementation, mimicking the actual tumor microenvironment in vivo . The cells were treated with anti-cancer drugs according to a gradient concentration generator inside the chips to screen the appropriate chemotherapy schemes. We successfully cultured cell lines or primary cells with this device. We also smoothly assayed the sensitivities of different anti-cancer drugs in parallel and accurately screened appropriate-dose, single and combined-drug chemotherapy schemes for eight patients. Our microfluidic device is a simple, reliable, and high-throughput platform to test drug sensitivity. It would be possible for chemotherapists to screen the appropriate chemotherapy schemes to guide individualized treatment in lung cancer.
Biography
Wenxin Wang obtained his B.Sc in Polymer Science and Engineering at Si Chuan University, followed by his M.Sc and Ph.D. at Shanghai Jiao Tong University. After his Ph.D., Dr. Wang worked as Technology Officer at Shanghai Huayi Group for ayear. In 2000, Dr. Wang was awarded Services Federaux des Affaires Scientifiques Fellowship and worked at the Centre for Education and Research on Macromolecules at the University of Liege, Belgium for one year. From 2001 to 2008, Dr. Wang was a senior research fellow at the University of Nottingham, UK. In 2008, Dr. Wang joined NUI Galway in Ireland. Dr. Wang is the Science Foundation Ireland (SFI) Stokes Lecturer on Functional Biomaterials in the Department of Mechanical and Biomedical Engeering and Network of Excellence for Fuctional Biomaterials.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords