Characterization Of Global MicroRNAs In Horse Tissues | 9225
Journal of Clinical & Experimental Pathology
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The microRNA (miRNA) is small, non-encoding RNA and plays important role in various biological conditions by regulating
the expression of target gene at the post-transcriptional level. miRNAs are involved in the normal functioning of eukaryotic
cells, and dysregulation of miRNA been associated with various diseases including inherited disorders, cancer, cardiomyopathy,
and obesity. The expression profile of miRNA is specific for the tissue, indicating a potential value of miRNAs as a biomarker
for disease diagnosis and prognosis. Research about miRNAs in veterinary medicine is in infant stage. Especially, no baseline
laboratory data about equine miRNAs are available. In the present study, global profile of equine miRNAs was investigated in
blood and several tissues by Next Generation Sequencing (NGS) technology. A total of 306 known miRNAs that reported in
miRbase were identified and 95 miRNAs were commonly found in different organs including muscle, colon and liver. Distinct
set of tissue miRNAs were also present in the serum. The present study revealed lists of miRNAs expressed in the major organs,
suggesting that blood miRNAs could be utilized as a biomarker for tissue damage. The present study provides valuable background
information for further studies about the development of diagnostic tool for equine diseases.
Yongbaek Kim has completed combined program of Ph.D. and resident training of veterinary anatomic pathology from The University of Georgia
and postdoctoral studies from National Institute of Environmental Health Sciences. He is the board certified veterinary pathologist and serving as an
Associate Director of Veterinary Medical Teaching Hospital of College of Veterinary Medicine, Seoul National University. He has published more than
40 papers in reputed journals and has been serving as an editorial board member of multiple journals.
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