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Chondro Myxoid Fibroma Of Skull Base- A Pathological Dilemma | 16433
Journal of Clinical & Experimental Pathology
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Chondro-myxoid fibroma is relatively uncommon & is estimated to represent less than 1% of all primary bone neoplasms.
Often seen in young adults during the second & third decades of life & usually arising from the metaphysis of major long
bones of lower extremities. Head & Neck involvement remains a rare site & is thought to mainly arise from the synostosis
at the base of skull or from sutures. This tumor may also arise from the embryonic cartilage residue. Jaffe & Lichtenstein in
1948 originally distinguished this tumor from other aggressive cartilaginous tumors. WHO defined it as a benign tumor
characterized by lobules of spindle shaped or stellate cells with abundant myxoid or chondroid intercellular material separated
by zones of more cellular tissue rich in spindle shaped or round cells with a varying number of multinucleated giant cells
of different sizes. Establishing histological diagnosis of chondromyxoid fibroma involving skull base becomes all the more
difficult because of its similarities with chondrosarcoma thus creating a trap for pathologists. Distinction between these two
tumors is important due to their different management strategies. Here we present a case of chondro myxoid fibroma of
right infra-temporal fossa treated by surgery alone, emphasizing more on the pathological aspects of diagnosis & differential
diagnosis. A good knowledge of this clinical entity should avoid incorrect diagnosis.
M. Ehtaih Sham, completed his graduation in 1997, worked as a registrar in craniofacial unit, before completing his masters in 2002. Following masters, he worked
in various capacities in plastic and reconstructive surgery and craniofacial units at different specialty hospitals. He worked as a senior fellow resident at Kidwai
institute of oncology, which is the regional cancer center for the state of Karnataka, India. Prof. Sham completed his medicine in 2008 from Khazar University,
Europe. Prof. Sham completed his fellowship in head & neck micro vascular reconstruction from Amrita Institute of Medical Sciences, India. Presently he is
visiting Paris, France for masters in reconstructive microsurgery at Institute Gustav Roussy. Presently he is Professor in department of craniofacial surgery at
Vydehi institute of medical and dental sciences and research center, and heads the micro vascular unit of head & neck reconstruction. He is actively involved in
postdoctoral research in craniofacial reconstruction and stem cell research.
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