Journal of Clinical & Experimental Pathology
Open Access

Abstract

Statement of the Problem: COVID-19 has varied clinical manifestations and prognoses. Many factors influence clinical manifestations and prognosis in COVID-19 patients, including sex, age, comorbidities, immune status, variant of SARS-CoV-2 and therapy. Quick response is needed by health workers when dealing with COVID-19 patients. In Indonesia, as a developing country, PCR examination takes 24 hours. Therefore, establishing a temporary diagnosis from a history of infection, sign, symptom and simple laboratory examination are the first things to do when the COVID-19 patient comes to the emergency room. In addition, it is also necessary to determine the prognosis when they first arrived to be able to provide adequate treatment. CRP (C-reactive protein) is acute phase reactant protein that can predict the severity of COVID-19 patients. Beside that, viral infections can affect several hematologic markers. Therefore, it is necessary to evaluate hematologic markers in COVID-19 patients when they first come to the emergency room. The purpose of this study was to determine the relationship between platelets count and NLR (neutrophil lymphocyte ratio) on CRP (C-reactive protein) in COVID-19 patients in Jember regency. Methodology & Theoretical Orientation: This study used an observational analysis approach using secondary data from COVID-19 patient�s medical records. Using platelets count, NLR and CRP of COVID-19 patients from June to August 2021. Of the 30 patients who were research subjects, 23 were treated in non-ICU rooms and 7 were treated in ICU rooms. Findings: Pearson analysis results for correlation between platelets counts with CRP and NLR with CRP obtained p = 0.001, r = -0.733 and p = 0.000, r = 0.889, respectively. Conclusion & Significance: There is strong negative correlation between platelets count and CRP. In addition, there is a very strong positive correlation between NLR and CRP. The correlation between platelets count and NLR on CRP are related to prognostic and predictive factors of severity in COVID-19 patients. Platelet counts and NLR can replace CRP as a marker to predict severity in patients diagnosed with COVID-19.

Biography

Rini Riyanti has expertise in clinical pathology and is interested in studying the clinical and laboratory aspects of COVID-19. She is a teaching staff at the Faculty of Medicine, University of Jember. During the COVID-19 Pandemic, She worked in a clinical pathology laboratory that carry out laboratory tests and PCR tests for COVID-19 patients.