Reach Us +1-947-333-4405


Decline In Frozen Section Diagnosis Of Sentinel Lymph Nodes For Breast Cancer As A Result Of The ACOSOG Z0011 Trial | 63346
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Google scholar citation report
Citations : 1147

Journal of Clinical & Experimental Pathology received 1147 citations as per google scholar report

Journal of Clinical & Experimental Pathology peer review process verified at publons
Indexed In
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Open J Gate
  • Genamics JournalSeek
  • JournalTOCs
  • Ulrich's Periodicals Directory
  • RefSeek
  • Hamdard University
  • OCLC- WorldCat
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
Share This Page

Decline in frozen section diagnosis of sentinel lymph nodes for breast cancer as a result of the ACOSOG Z0011 trial

12th International Conference on Pediatric Pathology & Laboratory Medicine

Mary Ann G Sanders

University of Louisville, USA

Keynote: J Clin Exp Pathol

DOI: 10.4172/2161-0681.C1.030

Statement of the Problem: Results of the multicenter American College of Surgeons Oncology Group (ACOSOG) Z0011 trial published in 2011 showed that patients with early-stage breast cancer and limited sentinel lymph node (SLN) metastasis treated with breast conserving surgery and systemic therapy did not benefit from axillary lymph node dissection (ALND). The Z0011 trial was practice changing for the surgical management of breast cancer, and in turn, has proven to be equally impactful on the pathologic diagnosis of SLNBs. The purpose of this study is to demonstrate the impact of the Z0011 trial on intraoperative frozen section diagnosis of SLNBs. Methodology & Theoretical Orientation: This is a retrospective study reviewing pathology reports from patients with primary breast cancer who met Z0011 trial clinical criteria and were initially treated with lumpectomy and SLNB from 2009 to 2015. Findings: SLNBs sent for frozen section diagnosis ranged from 68% to 100% before Z0011 and declined to just 2% of cases after the Z0011 trial results were published in 2011. Of the post-Z0011 cases 19% had SLNs with metastasis and 97% of patients were spared ALND. Conclusion & Significance: Following publication of the Z0011 trial results, intraoperative frozen section diagnosis of SLNs significantly decreased at our institution. Given that the vast majority of patients did not require second surgery for completion ALND, routine frozen section diagnosis for SLNB can be safely avoided in patients who meet Z0011 criteria, sparing patients the prolonged anesthesia time associated with waiting for frozen section diagnosis results and decreasing health care costs related to extra charges incurred with frozen section diagnosis.

Mary Ann G Sanders has received her Bachelor's degree from the University of Wisconsin-Madison. After she obtained her MD and PhD degrees from Washington University in St. Louis, she completed an Anatomic Pathology and Clinical Pathology Residency at the University of Louisville followed by a Breast Pathology Fellowship at the Brigham and Women’s Hospital, Harvard Medical School. She joined the Department of Pathology at the University of Louisville in 2011 as an Assistant Professor and Breast Pathologist for James Graham Brown Cancer Center. She is an Associate Program Director for Pathology Residency Program at the University of Louisville.

Email: [email protected]