Decline In Frozen Section Diagnosis Of Sentinel Lymph Nodes For Breast Cancer As A Result Of The ACOSOG Z0011 Trial | 63346
Journal of Clinical & Experimental Pathology
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Statement of the Problem: Results of the multicenter American College of Surgeons Oncology Group (ACOSOG) Z0011
trial published in 2011 showed that patients with early-stage breast cancer and limited sentinel lymph node (SLN) metastasis
treated with breast conserving surgery and systemic therapy did not benefit from axillary lymph node dissection (ALND).
The Z0011 trial was practice changing for the surgical management of breast cancer, and in turn, has proven to be equally
impactful on the pathologic diagnosis of SLNBs. The purpose of this study is to demonstrate the impact of the Z0011 trial on
intraoperative frozen section diagnosis of SLNBs.
Methodology & Theoretical Orientation: This is a retrospective study reviewing pathology reports from patients with primary
breast cancer who met Z0011 trial clinical criteria and were initially treated with lumpectomy and SLNB from 2009 to 2015.
Findings: SLNBs sent for frozen section diagnosis ranged from 68% to 100% before Z0011 and declined to just 2% of cases
after the Z0011 trial results were published in 2011. Of the post-Z0011 cases 19% had SLNs with metastasis and 97% of patients
were spared ALND.
Conclusion & Significance: Following publication of the Z0011 trial results, intraoperative
frozen section diagnosis of SLNs significantly decreased at our institution. Given that the vast
majority of patients did not require second surgery for completion ALND, routine frozen
section diagnosis for SLNB can be safely avoided in patients who meet Z0011 criteria, sparing
patients the prolonged anesthesia time associated with waiting for frozen section diagnosis
results and decreasing health care costs related to extra charges incurred with frozen section
Mary Ann G Sanders has received her Bachelor's degree from the University of Wisconsin-Madison. After she obtained her MD and PhD degrees from Washington University in St. Louis, she completed an Anatomic Pathology and Clinical Pathology Residency at the University of Louisville followed by a Breast Pathology Fellowship at the Brigham and Women’s Hospital, Harvard Medical School. She joined the Department of Pathology at the University of Louisville in 2011 as an Assistant Professor and Breast Pathologist for James Graham Brown Cancer Center. She is an Associate Program Director for Pathology Residency Program at the University of Louisville.