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Objective: This study aimed to analyze diagnostic disparities encountered while dealing with major salivary gland malignancies
and implicates its role in deciding whether to resort only to the FNAC reports in major salivary gland lesions to determine the
treatment plan to avoid under treatment in malignant lesions having benign FNAC diagnosis.
Methodology: A retrospective analysis of treatment records of major salivary gland tumors operated in the Department of
Otolaryngology and Head and Neck Surgery from August 2008 to July 2014 was done. Those having discrepancy between
FNAC and post-operative biopsy were further reviewed to evaluate the accuracy of the FNAC and biopsy diagnoses given
earlier by reexamination of the slides.
Results: A total of 128 surgeries including 13 revision surgeries were performed for 113 parotid, 14 submandibular gland and
one sublingual gland lesions. These surgeries were performed on 72 males with 17 malignant, 54 benign and one metastatic
lesion and 56 females with 13 malignant and 43 benign lesions. 5 out of 128 (3.90%) surgeries performed on FNAC proven
benign lesions were found to be malignant in the post-operative biopsy. 4 FNAC diagnosed cases of pleomorphic adenoma
were found to be mucoepidermoid Ca in 2 cases and adenoid cystic Ca and epithelial myoepithelial Ca in one case each. One
case of Warthin�s tumor was post-operatively diagnosed as mucoepidermoid Ca.
Conclusion: With such an incidence (5 of 128 i.e., 3.90%) of under diagnosis of major salivary gland lesions in preoperative
FNAC questions the diagnostic accuracy of fine needle aspiration cytology. In view of the mimicking cytological pictures
leading to a misdiagnosis seen both in the present study and in the literature, guide the clinician to decide surgical planning
based on clinical, radiologic and intraoperative findings along with the FNAC rather than FNAC alone.