Otolaryngology: Open Access
Open Access

Abstract

Background: Diff erent delivery modes may aff ect the susceptibility to allergic diseases. It is still unknown whether early intervention with probiotics would counteract this eff ect. Objectives: Th e eff ect of diff erent delivery modes on immune status and nasal symptoms was investigated on established allergic rhinitis (AR) mouse model. In addition, the immunoregulatory eff ects and mechanisms of diff erent feeding manners with Bifi dobacterium breve were examined. Methods: Live lyophilized B. breve was orally administered to BALB/c mice born via vaginal delivery (VD) or cesarean delivery (CD) for 8 consecutive weeks, aft er which they were sensitized by ovalbumin (OVA) to establish experimental AR. Nasal symptoms, serum immunoglobulins, cytokines, splenic percentages of CD4+CD25+Foxp3+ regulatory T(Treg) cells and nasal eosinophil infi ltration were evaluated. Results: Compared with VD mice, mice delivered via CD demonstrated more serious nasal symptoms, higher concentrations of OVA-specifi c immunoglobulin (Ig) E, more nasal eosinophil and lower percentages of splenic CD4+CD25+Foxp3+Treg cells aft er establishing experimental AR. Th ese parameters were reversed by administering B. breves shortly aft er birth. However, the eff ect of B. breve did not diff er between diff erent delivery modes. Conclusion: CD aggravates the nasal symptoms of AR mice compared to VD. Th is is the fi rst report that oral administration of B. breve shortly aft er birth can signifi cantly alleviate the symptoms of AR mice born via both deliveries, probably via activation of the regulatory capacity of CD4+CD25+Foxp3+Treg cells.

Biography

Yang Xu is currently pursuing his PhD in West China School of Medicine, Sichuan University, China. He focuses on scientifi c research about rhinology and otology.