alexa
Reach Us +1-947-333-4405
Effects Of Fractionated Methanolic Leaf Extract Of Gongronema Latifoliumon CCl4-induced Wistar Albino Rats | 92083
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Recommended Conferences
Share This Page

Effects of fractionated methanolic leaf extract of Gongronema latifoliumon CCl4-induced wistar albino Rats

Joint Event on 6th World Congress and Expo on Breast Pathology and Cancer Diagnosis & 20th International Conference on Medicinal Chemistry and Rational Drugs

Okpala and Jude Chinedu

Ahmadu Bello University, Nigeria National Biotechnology Development Agency, Nigeria

ScientificTracks Abstracts: J Clin Exp Pathol

DOI: 10.4172/2161-0681-C3-051

Abstract
The general aim of this study is to assess the effects of fractionated methanolic leaf extract of Gongronema latifoliumon CCl4-induced wistar albino rats. Fifty-four wistar albino rats were divided into seven treatment groups. Group A was given feed and water, Group B was injected with olive oil intraperitoneally, while the rest of the groups (C, D, E, F and G) were injected intraperitoneally with a single dose of CCl4 (148 mg/kg). After 36 hours of induction, group E, F and G were given 100 mg/kg, 150 mg/kg and 200 mg/kg body weight of n-butanol fraction of methanol leaf extract of Gongronema latifolium by oral gavage. Group D was given 100 mg/kg of silymarin (standard drug) where as group C served as CCl4-induced group. At the end of 28 days of treatment, there were significant (P<0.05) reduction in PCV, Hb concentration and serum protein levels as well as a significant (P<0.05) increase in percentage change in liver weights of CCl4-induced control rats when compared with the induced treated groups. Liver marker enzymes studies showed that there was significant (P<0.05) increase in the serum activities of ALT, AST, ALP and bilirubin concentrations in CCl4-induced control group when compared with the induced treated groups. Antioxidant assay on the liver homogenate showed that there was significant (P<0.05) decrease in SOD, CAT, GPx and a significant increase (P<0.05) in MDA of CCl4-induced control rats when compared to the induced treated and normal control groups. These findings suggested that n-butanol fraction of methanol leaf extract of G. latifolium may have anti-hepatotoxic and antioxidative effects against CCl4-induced liver damage rats.
Biography

Okpala, Jude Chinedu is currently a PhD student at the Department of Biochemistry, Ahmadu Bello University where he also did his Masters Degree programme. He also attended Ebonyi State University, Abakaliki where he bagged his Bachelor of Science Degree. He is currently an independent researcher and has published several papers in reputed journals. He has also served as an editorial board member of several journals.

E-mail: [email protected]

Top