Journal of Clinical & Experimental Pathology
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Cellular spheroid structures (CSS) were found in stem cell and tumour cell cultures. It was supposed that they may play
an important role in regeneration and tumorogenesis. The arising and significance of CSS in HPV associated precancer
and cancer lesions of uteri cervix are not still investigated
. The goal of the study was to analyze CSS morphology and
molecular-biological characteristics of CSS in HPV-associated cervical pathology. Biopsy material (paraffin sections) from 223
women with HPV associated chronic cervetites, CIN 1; CIN 2-3 was investigated. Immunohistochemical detection of OCT4,
CD34, Vimentin, CD44, E-cadherin,p16, Ki67, CK7, SMA and in situ hibridization analyses of HPV DNA (16, 18, 33, 54,
56 types) were performed. It was found that CSS are formed in basal-parabasal layers of squamous epithelium and adjacent
myofibroblasts transitional zone. HPV DNA was detected in epithelial and endothelial cells of CSS. There are two structural
and functional types of CSS ? repair CSS and tumor CSS, that differ by capillary content and oncomarkers expression. OCT4
and Vimentin positive cells localize in peripheral regions in colonies of CSS.
Evgeniya Kogan is Chief of Pathology Department of RF Research Center of Obstetrics, Gynecology and Perinatology and Professor of the Anatomic Pathology
Department of The I.M.Sechenov Moscow Medical University. 1991 - Doctor of Science in Medicine, Doctoral Thesis: ?Morphogenesis of Peripheral Lung Cancer?.
Since 1995 she is a Member of Russian Division of the International Academy of Pathology and Chief of Russian Division of International Society of EM and
Immunocytochhemistry. She is the author of 12 monographers and more than 120 publications in scientific journals. Fields of research ? clinical pathology,
pulmonology, gynecology and general pathology (oncomorphology, repair, inflammation).
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