alexa Evaluation Of Human Epidermal Growth Factor Receptor (HER-2/neu) In Gastric Adenocarcinoma: A Study From South Asia Region | 63354
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

12th International Conference on Pediatric Pathology & Laboratory Medicine

Asma Shabbir, Muhammad Asif Qureshi, Talat Mirza and Abdullah Bin Khalid
Jinnah Sindh Medical University, Pakistan
ScientificTracks Abstracts: J Clin Exp Pathol
DOI: 10.4172/2161-0681.C1.031
Abstract
Background & Aim: Gastric cancer is the third leading cause of cancer mortality worldwide. Human epidermal growth factor (HER- 2/neu) has shown strong therapeutic implication in breast cancer. Expression of HER-2/neu in gastric cancer has been reported from across the world, it is still unknown from South Asia region. The aim of this study is to evaluate HER-2/neu expression in gastric adenocarcinomas and to correlate with various clinicopathological variables. Patients & Method: A total of 95 consecutive patients undergoing endoscopic biopsy or gastrectomy were recruited in this study after institutional ethical approval. Clinicopathological parameters of all patients were recorded and hematoxylin and eosin (H&E) staining was performed. Expression of HER-2/neu was investigated by immunohistochemistry using α-HER-2 antibody. Hofmann validation scoring system was used and its association was seen with various clinicopathological variables including age, gender, histopathological type, grade and stage of the tumor. Results: HER-2/neu over expression was found in 21 (22.1%) cases from the total of 95 gastric adenocarcinomas. HER-2/neu was significantly expressed in low grade gastric cancer (p=0.030). Although there was no significant difference between HER-2/neu expression and other variables, HER-2/neu score 3+ was higher in females, age >60 years, Laurens intestinal type and IIIC stage. Conclusion: HER-2/neu is expressed in a limited group of gastric cancer patients in Pakistani population. Our findings indicate a significant strong association of HER-2/neu expression with low grades of gastric cancer.
Biography

Asma Shabbir has done her MBBS from B J Medical College, Pune, India. She has done her Post-graduation from Dow International Medical College, Karachi, Pakistan. She has a passion towards research and concerned for better prognosis of the patient. She has presented her research work in many conferences. Recently, she received the Young Researcher Award at the International Conference of Digestive Diseases in Dubai 2016. She is a member of different scientific and research associations. At present, she is working as a Researcher and as an Assistant Professor in the Department of Pathology, Jinnah Sindh Medical University, Pakistan.

Email: [email protected]

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7