Reach Us +1-947-333-4405


Evolution Of The Bladder Cancer Genome From Field Effects | 16397
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Recommended Conferences

World Congress on Pathology and Microbiology

Manila, Philippines
Google scholar citation report
Citations : 1147

Journal of Clinical & Experimental Pathology received 1147 citations as per google scholar report

Journal of Clinical & Experimental Pathology peer review process verified at publons
Indexed In
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Open J Gate
  • Genamics JournalSeek
  • JournalTOCs
  • Ulrich's Periodicals Directory
  • RefSeek
  • Hamdard University
  • OCLC- WorldCat
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
Share This Page

Evolution of the bladder cancer genome from field effects

3rd International Conference and Exhibition on Pathology

Bogdan Czerniak

Keynote: J Clin Exp Pathol

DOI: 10.4172/2161-0681.S1.011

We developed a strategy that combines histologic and genetic mapping that permits interrogation of the chronology of genetic changes associated with cancer development on a whole-organ scale. By using this approach, we analyzed the sequence of genetic alterations contiguous to the tumor suppressor RB1 and identified a set of alternative target genes that we term ?forerunner? (FR) genes whose silencing was associated with development of clonal plaque-like mucosal field effects initiating bladder carcinogenesis. Expression and methylation studies identified five candidate FR genes ( ITM2B, LPAR6, MLNR, CAB39L, and ARL11 ). In vitro mechanistic studies demonstrated that three of these genes ( ITM2B, LPAR6 and ARL11 ) control cell survival and proliferation consistent with their loss of function being contributory to tumorigenesis. Whole genome analyses of the field effects revealed a sequential accumulation of alterations in RHO/RAC/Cdc42 pathways that control invasion and cell motility. These studies identify FR genetic alterations as one of the earliest events in carcinogenesis and provide comprehensive description of field cancerization. The results have important implications for the development of novel detection markers and chemoprevention therapeutic strategies.
Bogdan Czerniak, MD, Ph.D. is a Professor in the Department of Pathology at UT MD Anderson Cancer Center. His laboratory is credited with the development of a mapping strategy which has provided unique information on the events associated with the development of field effects initiating carcinogenesis. Dr. Czerniak has published over 160 articles in major journals such as Nature, Cancer, Cancer Cell, JNCI, Cancer Research and Plos One.