Expression Of Cancer Stem-like Cell Markers In Papillary Thyroid Cancer: An Immunohistochemical Analysis | 98868
Journal of Clinical & Experimental Pathology
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Purpose: Cancer stem-like cell markers are reported be related to the prognosis of various cancers. The aim of this study was to
investigate the clinical significance of stem-like cell markers in papillary thyroid carcinoma (PTC).
Methods: We constructed tissue microarrays with 386 PTC cases. The expression of cancer stem-like cell markers was estimated
using immohistochemical (IHC) staining for CD24, CD15, CD166, CD44, and ALDH1A1. The scores of IHC staining was
calculated by multiplying the proportion of stained cells and immunostaining intensity, and was defined positive when the final
score was >10. Associations between the expression of cancer stem-like cell markers between the clinicopathologic parameters
were evaluated. Disease progession was defined as those experiencing recurrence or distant metastasis.
Results: Among the patients included, a total of 59 patients experienced recurrence or distant metastasis during the follow-up.
The proportion of CD15, CD166, CD44, and ALDH1A1 expression were higher in PTC patients with disease progression than
without (p=0.014, <0.001, = 0.019, and <0.001, respectively). In multivariate Cox-proportional hazard analysis, CD15 positivity,
CD166 positivity, and ALDH1A1 positivity were an independent factor for shorter progression free survival (odds ratio: 2.113,
7.413, and 2.574, 95% CI: 1.253-3.564, 4.296-12.791, and 1.014-6.360, p = 0.005, <0.001, and =0.041, respectively) along with the
presence of lymph node metastasis.
Conclusion: Expression of cancer stem-like cell markers CD15, CD166, CD44, and ALDH1A1 in PTC was associated with
shorter progression free survival. These findings suggest that cancer stem-like cell markers might provide useful information in
predicting patient prognosis in PTC.
Hye Min Kim has completed her residency in the Department of Pathology in Severance Hospital, Seoul, South Korea in 2016, and achieved a PhD degree at the age of 30 in Yonsei University College of Medicine. From the year of 2016, she is in a fellowship program in the department of Pathology of Severance Hospital.