Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar
Expression Of Cytokines In Tissues And Correlation With Histopathological Changes In Dengue Fatal Cases From Brazil | 9197
Journal of Clinical & Experimental Pathology
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
The pathogenesis of dengue hemorrhagic fever (DHF) is complex and not well defined. In the present work, we initiated a
study with tissues obtained from different organs (liver, lung, heart and kidney) of four dengue fatal cases. The history of
patients and correlation with histopathological damages and cytokine expression were the main focus of this work. All patients
presented symptoms of DHF, such as headache, myalgia, anorexia, rash maculopapular, diarrhea, petechial bleeding, pulmonary
congestion, edema and hemorrhage. The progression of symptoms correlated with co-morbities, especially diabetes and obesity
(cases 1 and 2, respectively). The heart of case 1 showed ischemic myocarditis, confirmed by histopathological aspects, and we
observed areas with diffuse edema and degeneration cardiac fibers. The expression of cytokines in the ischemic heart showed a
predominance of anti-inflammatory cytokine (TGFβ). On the other hand, in case 2 we observed extensive areas with steatosis
(micro and macrovesicular) and necrosis in the liver and pulmonary disorders, such as thickened alveolar septa and hypertrophy
of alveolar macrophages resulting in an increase of pro-inflammatory cytokines in both organs. The kidney of case 2 also presented
acute tubular necrosis, with increased number of macrophages cells, with pro and anti-inflammatory cytokines. In all organs of
the four cases studied, we observed areas with tissue injuries with high expression of RANTES. The different pathological aspects
in the tissues of the four dengue cases, as well as the different cytokine profiles in each organ, suggest a compartmentalization of
the immune system in these organs.
Marciano Viana Paes had done his Ph.D. in Cellular and Molecular Biology in the area of Virology/Pathology of dengue. He is a researcher in public
health at the Oswaldo Cruz Foundation and working with pathology of fatal cases of dengue and experimental models from past 10 years.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals