alexa
Reach Us +1-947-333-4405

GET THE APP

Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar
Extremely Potent, Pan-genotypic Hepatitis C Virus NS5A Inhibitors Based On Novel Core Structures | 92064
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Google Scholar citation report
Citations : 1218

Journal of Clinical & Experimental Pathology received 1218 citations as per Google Scholar report

Journal of Clinical & Experimental Pathology peer review process verified at publons
Indexed In
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Open J Gate
  • Genamics JournalSeek
  • JournalTOCs
  • Ulrich's Periodicals Directory
  • RefSeek
  • Hamdard University
  • EBSCO A-Z
  • OCLC- WorldCat
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
Share This Page

Extremely potent, pan-genotypic Hepatitis C virus NS5A inhibitors based on novel core structures

Joint Event on 6th World Congress and Expo on Breast Pathology and Cancer Diagnosis & 20th International Conference on Medicinal Chemistry and Rational Drugs

B Moon Kim

Seoul National University, Republic of Korea

Keynote: J Clin Exp Pathol

DOI: 10.4172/2161-0681-C3-050

Abstract
Hepatitis C virus (HCV) infection often leads to serious liver diseases such as cirrhosis followed eventually by hepatocellular carcinoma. Several HCV RNA gene products (NS2, NS3, NS4A, NS4B, NS5A and NS5B) involved in the reproduction of HCV have been instensively studied for new therapeutic target identification. Recently, combinations of direct acting antivirals (DAA) including HCV NS3/4A protease inhibitors such as boceprevir, telaprevir, paritaprevir, and grazoprevir, polymerase inhibitors such as sofosbuvir and dasabuvir, and NS5A inhibitors such as daclatasvir, ledipasvir, ombitasvir, elbasvir and velpatasvir have shown successful arrest of the infection. However, even with the new DAA’s, resistance to the drugs in patients infected with various strains of HCV has emerged. Therefore development of effective anti-HCV drug candidates possessing pan-genotype activities is still needed. Herein we report the discovery of a series of extremely potent HCV NS5A inhibitors based on a few new core skeletons. From these efforts, we have identified a series of NS5A inhibitors that exhibit highly potent anti-HCV activities particularly against several genetic variants and some mutant strains. Several interesting compounds were further evaluated with other studies and are shown to be nontoxic and anticipated to be effective HCV drug candidates.
Biography

B Moon Kim has completed his PhD and postdoctoral studies at M.I.T. After 5 year experience at Merck Research Laboratories in USA, he took a faculty position at the Chemistry Department of Seoul Naitonal University Korea. He was Chemistry Department Chair and Director of the BK21 Chemistry & Molecular Engineering Division at SNU. He has published more than 120 papers and 25 patents and has been serving as an editorial board member of Bioorganic Medicinal Chemistry and Bioorgnaic & Medicinal Chemistry Letters and an editor-in-chief of Bulletin of the Korean Chemical Society.

E-mail: [email protected]

Top