FTIR Spectroscopy Together With Neural Network Approach In The Study Of Radioprotectantamifostine - Rat Tissue And Membrane Interactions In Irradiated And Healthy Systems | 3134
Journal of Clinical & Experimental Pathology
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Fourier transform infrared (FTIR) spectroscopy/microscopy can be successfully used to monitor pathology-induced structural
and functional molecular changes in biological systems. Amifostine (WR-2721) is the only approved radioprotective agent
by the Food and Drug Administration (FDA). Here, using FTIR spectroscopy/microscopy together with neural network (NN)
approach, the restoring effect of amifostine on ionizing radiation-induced damages and the sole effects of amifostine on lipids
and proteins of healthy rat liver microsomal membranes and brain tissues are reported. NN approach is commonly used to
predict the protein secondary structure. The results revealed that radiation induced significant alterations in the concentration,
composition, structure and function of lipids in the liver microsomal membranes  and white matter (WM) and grey matter
(GM) regions of brain tissues  and amifostine restores radiation-induced damages in these systems. Radiation also causes
significant changes in the secondary structure of proteins by inducing an increase in the turn and random coil structures
which are restored by amifostine treatment [1,2]. However no significant changes were observed in healthy systems in terms
of molecular concentration, lipid structure and protein secondary structure due to amifostine which indicated that amifostine
is non-toxic for the biological systems and can be successfully used as a radioprotectant agent in radiotherapy. Supported by
TUBITAK-SBAG-2939) and METU.
Feride Severcan completed her M.Sc. from Rochester University, Ph.D. from Hacettepe University, postdoctoral study from Stanford University. She worked as a lecturer and researcher in San-Francisco State University, visiting scientist in Perugia, Bath and De-Montford Universities. She joined to the Biology Department of METU as a Professor of Biophysics, where she chaired the Department for three years. She is the leader of the Molecular Biophysics research group and published more than 100 papers in SCI journals. Dr. Severcan has several book chapters and a Book on Vibrational Spectroscopy on Screening and Diagnosis (IOS Press-2012) and serving as an editorial board member of two spectroscopy journals.
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