Journal of Clinical & Experimental Pathology
Open Access

Abstract

The ENISI Visual, an agent-based simulator for modeling gut immunity to enteric pathogens. Gastrointestinal systems are important for in-taking food and other nutritions and gut immunity is an important part of human immune system. ENISI Visual provides quality visualizations and users can control initial cell concentrations and the simulation speed, take snapshots, and record videos. The cells are represented with different icons and the icons change colors as their states change. Users can observe real-time immune responses, including cell recruitment, cytokine and chemokine secretion and dissipation, random or chemotactic movement, cell-cell interactions, and state changes. The case study clearly shows that users can use ENISI Visual to develop models and run novel and insightful in silico experiments.

Biography

Josep Bassaganya-Riera is the Director of the Nutritional Immunology and Molecular Medicine Laboratory (www.nimml.org) at VBI. He has held and currently holds many research grants from various sources including the National Institutes of Health, the United States Department of Agriculture, and industrial corporations. He is the Principal Investigator and Director for the Modeling Immunity to Enteric Pathogens (MIEP) project, a $10.6 million Center that investigates the immunoregulatory mechanisms underlying infections with gut pathogens by applying mathematical systems to mucosal immunology. He is also Principal Investigator on an RO1 award designed to study the mechanisms of immune modulation by abscisic acid. Bassaganya-Riera has published over 70 scientific papers, 3 patents and manages a research portfolio of $12M.