Journal of Clinical & Experimental Pathology
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LIF derives has been described as a pleiotropic cytokine with effect on the growth promotion and cell differentiation of
different types of target cells, with influence on bone metabolism, embryogenesis and inflammation. P53 regulated LIF has
been shown to facilitate implantation in the mouse model and possibly in humans. It is suggested that recombinant human LIF
might help to improve the implantation rate in women with unexplained infertility.
The aim of this study is to demonstrate the expression of leukemia inhibiting factor in different endometrial locations &
compare it in fertile & infertile women.
Histopathological examination & immunohisto chemical expression of Leukemia inhibiting factor (LIF) of
endometrial specimens from (25 healthy fertile ladies & 25 cases with unexplained infertility) in different locations within
endometrial tissue i.e. luminal, glandular, as well as stromal, was done.
In cases of fertility LIF expression varied according to the phase of menstrual cycle. Secretory endometrium expressed
significantly higher LIF than proliferative endometrium with maximum expression in the midsecretory phase. In cases of
infertility the endometrium showed lower LIF expression during different phases of menstrual cycle in comparison with fertile
LIF is one of the important cytokines in reproduction & play a role in implantation & supports the endometrial
functions. Deregulation of this cytokine may be a cause of unexplained infertility.
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