MFG-E8 Expression For Progression And Self-clearance Of Apoptotic Cells In Oral Squamous Cell Carcinoma | 28296
Journal of Clinical & Experimental Pathology
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Milk fat globule-epidermal growth factor-factor VIII (MFG-E8) is a secreted glycoprotein that promotes clearance of
apoptotic cells by bridging phosphatidylserine on apoptotic cells and integrin ?v?3/5 on professional phagocytes.
Recently, high expression of MFG-E8 has been reported in various types of cancer in humans. Apoptotic figures are frequently
found in the surgical specimens of oral squamous cell carcinoma (SCC) and we have often observed apoptotic carcinoma
cells engulfed by macrophages or even by neighboring carcinoma cells. Thus we hypothesized that MFG-E8 might promote
engulfment of apoptotic carcinoma cells by living carcinoma cells and that MFG-E8 expressed by carcinoma cells could
contribute to tumor progression. The aim of this study was to elucidate the biological role of MFG-E8 in oral SCC. Fifty-three
surgical specimens of oral SCC were used for immunohistochemistry for MFG-E8. Also, we examined its function using MFGE8-
overexpressing cultured SCC cells. Most of the cases had MFG-E8-positive SCC cells and the expression of MFG-E8 was
correlated with such clinicopathological features as tumor size, pathological stage, locoregional recurrence, scattering invasion
pattern and SCC cell figures engulfing apoptotic SCC cells. The MFG-E8 staining was enhanced in apoptotic SCC cells, some
of which were apparently engulfed by the neighboring SCC cells. Transient MFG-E8 over expression in SCC cell lines increased
invasiveness and engulfment of apoptotic cells. Therefore we have demonstrated that MFG-E8 promotes tumor progression in
oral SCC and that it might be involved in the clearance of apoptotic SCC cells by living SCC cells.
Manabu Yamazaki is a Board Certified Oral Pathologist, Assistant Professor at the Division of Oral Pathology, Niigata University Graduate School of Medicine and
Dentistry working in research and practice of oral pathology.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals