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Mitochondrial Stress In Monocytes Is Reflected In Micro-vesicles And Associated With Metabolic And Coronary Artery Diseases | 60197
Journal of Clinical & Experimental Pathology
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Obesity’s negative impact on health is well-documented. Health consequences are categorized as being the result of either
increased fat mass (which leads to osteoarthritis, obstructive sleep apnea, social stigma) or an increased number of fat
cells (which contributes diabetes, cancer, cardiovascular diseases). Disease processes increasing risk in association with obesity
are subclinical chronic low-grade inflammation and oxidative stress which are also involved in development of cardiovascular
diseases. For example, recent data suggest that increased oxidative stress in adipose tissue is an early instigator of metabolic
syndrome. Given the number of symptoms and risk factors which characterize metabolic syndrome, the variability in
combinations of three out of five its components, and the variability in treatments and patient responses to treatment of those
symptoms, there remains a need in the art for identifying patients who are at risk for developing metabolic syndrome, T2D,
and/or cardiovascular diseases. In this study we discovered RNA expression patterns related to mitochondrial dysfunction and
oxidative stress in monocytes which were associated with metabolic syndrome and T2D, and identified an at-risk population
for new cardiovascular events in CAD patients. For the first time, we showed that signatures in monocyte-specific microvesicles
reflects these in monocytes and have similar predictive properties. We also found that identified gene signatures were
related to obesity and atherosclerosis in mice and pigs.
Paul Holvoet is a Professor in Biomedicine at the Department of Cardiovascular Sciences at the Catholic University of Leuven. His research focuses on the interaction between oxidative stress and inflammation in the pathogenesis of metabolic and cardiovascular diseases. He is a Fellow of the European Society of Cardiology and the American Heart Association. He is first inventor on international patents related to oxidized LDL and gene signatures in monocytes and derived exosomes. He is also a Co-Founder of Tank™.