alexa
Reach Us +1-947-333-4405
Nanocytology As A Novel Biomarker For Personalized Cancer Management | 9230
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd International Conference and Exhibition on Pathology

Jianyu Rao
Accepted Abstracts: J Clin Exp Pathol
DOI: 10.4172/2161-0681.S1.010
Abstract
Cancer is deadly because cancer cells invade and metastasize. Studies from us and others have showed that cell nanomechanical properties, e.g., cell elasticity, softness, and deformability, may be a new class of quantitative markers of tumor cell behavior. The aggressive tumor cells may be softer, more deformable, and less stiff and thereby have more flexibility and mobility than benign cells. The cell nanomechanic property is regulated by signal pathways of cytoskeletal remodeling. Using Atomic Force Microscopy and other state of art deformity cytometer, we measured the metastatic tumor cells obtained from remnants of patient?s body cavity fluid samples, and found a marked difference in softness and deformability between malignant cells and benign mesothelial cells present in the same sample, and common modulus of cell softness in different cancer types metastatic to body cavity. We further demonstrated that chemopreventive and therapeutic agents including green tea extract and other commonly used chemotherapeutic drugs have profound effect on cancer cell mechanics, and the measurements may be a marker for platin-based drug sensitivity. Works on primary tumors collected by fine needle aspiration and other cytological samples for example urine is now undertaking. Together, nanomechanical analysis can be performed on clinical cytological specimens, and Youngs modular E may be a quantitative functional biomarker that can be used for personalized cancer management. Combining cytomorphological analysis with molecular expression profiling as well as functional cancer cell mechanical measurements may bring the morphologically based cytology into the age of FUNCTIONAL nanocytology.
Biography
Jianyu Rao, is a tenured Professor in Pathology and Epidemiology at David Geffen School of Medicine, University of California at Los Angeles. He is the Chief of cytopathology section and Chief of gynecological pathology section at Department of Pathology and Laboratory Medicine of UCLA David Geffen School of Medicine. He is American Pathology Board-certified pathologist with sub-specialty board in cytopathology, a member of College of American Pathologist, a member of UCLA?s ACCESS graduate program, and a member of Jonsson Comprehensive Cancer Center. His clinical expertise is genitourinary tract pathology, gynecological pathology, and cytopathology. His main research interest is to study cytoskeletal actin remodeling in tumorigenesis and to develop biomarkers and new technologies, including nanotechnologies that can be used for cancer cell screening and diagnosis in either individualized therapeutic and population-based chemopreventive settings. He has 28 years of research experience in these areas, with over 100 publications and research funding from NIH, DOD, State, and private sources. Recently he is interested in adding nanomechanical analysis as a new dimension for functional cytological analysis of cancer cells.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2019-20
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri and Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

ankara escort

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

pendik escort

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2019 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version