New Insights On Molecular Signature Of Drug Resistance In Human Cancers | 9196
Journal of Clinical & Experimental Pathology
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Hypoxic markers have been found hyper-expressed at the invasive border of several solid human cancers and corresponding
metastases. Tumor carbonic anhydrase 9 (CAIX) is a key hypoxia regulated gene which is currently considered a reliable
tissue marker of tumor hypoxia.
The up-regulation of endogenous markers of different Hypoxia Response Pathways has been recently associated with tumor
aggressiveness and resistance to therapy.
CAIX is overexpressed in most of malignant metastasizing and/or radio/chemoresistant human tumors. However, it is still
unclear if its location (cellular/extracellular, or membrane/cytosolic or nuclear) could have a role in determining the biological
behaviour of tumors.
For this reason, we analyzed the immunohistochemical expression pattern of CAIX in a series of malignant tumors with
different histogenesis, with the aim to give further insights on the correlation between the site of expression of the protein and the
prognostic and predictive value of CA IX in solid human cancers.
The results of our study favour the hypothesis that the overexpression of CAIX
is not sufficient as a marker of biological
aggressiveness of solid tumours, whereas it reaches prognostic relevance when compared with the involved tissue compartment.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals