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Otosclerosis As A Neoplasm Of The Outer Layer Of The Otic Capsule | 38724
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We studied stained step sections embedded in celloidin of 54 temporal bones from 27 patients with otosclerosis at the
Royal National Throat, Nose and Ear Hospital, London and the House Ear Institute, Los Angeles, California, in order to
investigate the histopathologic changes in that disease of the otic capsule (OC). The outer layer of the normal OC is composed
of regularly arranged osteons (Volkmann��?s canals and osteocytes) formed from the primitive connective tissue covering the OC
externally. Otosclerosis is composed of multiple new plaques in the outer layer of the OC, each showing some resemblance to
the structure of the normal outer layer of OC bone. The plaques, however, have each a basophilic area composed of irregular
osteons comprising atypical osteoblasts with numerous, irregular Volkmann��?s canals. This has the appearance of an invasive
front leading the growth of the otosclerotic plaque. This invasive front is always on the side of the plaque opposite to the
periosteal surface of the involved temporal bone. Each plaque also shows increasingly more differentiated and paler-staining
bony tissue retrogressively towards the periosteal covering of the OC from which the plaque appears to arise. The invasive
front shows infiltration of the tissues that it contacts, by irregularly shaped, thin elongated processes of basophilic osteoblasts.
Such invaded tissues are often the inner layer of the OC and beyond this the cochlea and vestibule. Since otosclerotic plaques
are most commonly derived from the outer layer of OC near the periosteal connective tissue adjacent to the tensor tympani
muscle, the structures most often invaded by otosclerosis are the stapediovestibular joint and the stapes footplate. The presence
of multiple, similarly-structured plaques of otosclerosis, each with its undifferentiated invasive front edge and, posterior to that,
progressive differentiation of the otosclerotic bony lesion towards the primitive connective tissue base are strongly suggestive
of an invasive bony neoplasm of the OC. Otosclerosis has been in its long history rarely considered to be such a lesion. On the
basis of the histopathology we put forward here, we consider neoplasia to be the most like pathologic basis for this condition.
Biography
Leslie Michaels has completed his Medical education at Westminster Hospital Medical School in London in 1949. He has underwent training in both Clinical and Anatomical Pathology in Bristol, Manchester and London UK. He subsequently practiced Clinical and Anatomical Pathology in North America from 1959, spending most of the time in Northern Ontario, Canada. He has returned to London in 1970 as Pathologist to the Royal National Throat, Nose and Ear Hospital and Professor of ENT Pathology and Dean of the Institute of Laryngology and Otology. His main research interest has been in the pathology of the ear and he has contributed publication in this field. In recent years he has contributed particularly in the field of Meniere’s disease and otosclerosis.