Physiological Studies On The Effect Of Lepidium Sativum And Ursofalk (ursodeoxycholic Acid) Against The Toxicity Of Carbon Tetrachloride On Albino Rats | 16435
Journal of Clinical & Experimental Pathology
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Carbon tetrachloride (CC1
) is considered as one of the environmental pollutants induced toxicity in human and animals.
This study, was established five groups (n= 10) of Albino rats, (average body weight, 230-280g), to determine the therapeutic
sativum and ursofalk (ursodeoxycholic acid) against the toxicity of CC1
in most organs. The first groups
group (1) was received orally Nacl 0.9% and used as a normal group. Group (2) was injected intraperitoneal (i.p.) with CCl
(1 ml/kg), 3 times weekly, for 2 weeks (used as a control). Grpup (3) was given orally Ursofalk (100 mg/kg per body weight),
group (4) was given orally
(100 mg/kg body weight) and group (5) was given the same doses of Ursofalk plus
for 30 days respectively, post-injected intraperitoneal (i.p.) with CCl
(1 ml/kg) 3 times weekly, for 2 weeks.
All animals were sacrificed post-treatment. Two blood samples were collected, for hematological and biochemical parameters.
Specimens from most visceral organs were collected for histopathological examination. The obtained hematological and
biochemical results in control animals group (2) revealed a highly significant decrease in total RBCs, platelets, Hb and PCV,
serum uric acid, albumin, glucose, HDL-cholesterol, besides catalase, GSH, SOD activities in liver tissue, while WBCs, serum
ALT, AST, ALP, γ-GT, creatinine, urea, cholesterol, triglycerides and LDL-cholesterol levels, besides Malondialdehyde (MDA)
and Nitric Oxide (NO) levels in liver tissue showed a highly significant increase. Meanwhile, groups (3, 4 & 5) displayed
reverse effect in all parameters and return to normal especially group (5). The histological results displayed inflammation with
necrosis and degenerative changes in group (2), while remain groups showed mild changes particularly in group (5). It could
be concluded that CCl
induced severe destruction in most organs, which showed a clear improvement by using of Ursofalk
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