alexa
Reach Us +1-947-333-4405
Predictor The Significant Of Complications Of Pancreatic Pseudocysts | 9255
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd International Conference and Exhibition on Pathology

Yanina Naboichenko and Shevchenko R. S
Accepted Abstracts: J Clin Exp Pathol
DOI: 10.4172/2161-0681.S1.010
Abstract
Pseudocyst of the pancreas are the most common variant of local complications of acute pancreatitis, accounting for 50-92% of the destructive forms. In 81% of cases are pseudocysts complicated course. This is due to insufficiently developed their diagnosis and the lack of criteria for choice of treatment in these patients. The foregoing shows the relevance of the method of determining the indications for surgical treatment, and to identify markers of prognosis of complications of pancreatic pseudocysts Purpose: To examine the characteristics of free-radical processes in the body as a significant predictor of complications of pancreatic pseudocysts, depending on their degree of development. Materials and Methods: The analysis of the examination and treatment of 115 patients. Group A consisted of 25 healthy subjects (mean age 37 ? 8,6 years). Core group of 90 patients with pancreatic pseudocysts. The average age of patients with pancreatic pseudocysts was 46,9 ? 9,3 years (range 18 to 73 years). The complex diagnostic procedures included fibroezofagogastroduodenoscopy (FEGDS), ultrasound (U.S.), computed tomography (CT), endoscopic retrograde cholangiopancreatography (ERCP), and biochemical study of the contents of cysts. Diagnosis of the disease was performed by clinical symptom, according to instrumental and laboratory tests. Studies performed on patients with informed consent in accordance with ethical standards, regulated the Declaration of Helsinki 2000 Results and Discussion: There was a significant increase in the activity of G-6-PDG - the main enzyme pentose phosphate cycle, catalyzing the formation of reduced equivalents on immature pseudocysts of the pancreas in relation to patients with formed pseudocysts. Despite a significant increase in the activity of G-6-PDG, the level of reduced glutathione in immature pseudocysts remained lower than in the control group and patients with formed pseudocysts. The content of uric acid in all patients with pancreatic pseudocysts significantly higher than control values. However, in this case the operation of antioxidant protection was not effective in the group unformed pseudocysts, as evidenced by low levels of reduced glutathione and MDA high numbers in the blood of these patients. Marked inverse correlation between the content of malondialdehyde and glutathione in erythrocytes (Spearman's rank correlation coefficient r = - 896, p < 0,01). Thus, increased lipid peroxidation in immature pseudocysts of the pancreas occurs against the oppression of the components of the endogenous antioxidant systems like glutathione and glutathione reductase. Toxic effects of free radical oxidation products contributes to the maintenance of the inflammatory response and tissue ischemia in patients with immature pseudocysts of the pancreas. We observed a direct correlation between the content of MDA and ETA in plasma and erythrocytes (r = 0,845; p <0,05 and r = 0,883; p <0,05). The intensification of free radical oxidation and circulation of endotoxin substances in body fluids in various pathological processes inevitably lead to changes in the immune system of the body (10-13). As a result of the study, the following conclusions: 1. Pseudocyst of the pancreas characterized by non-specific polymorphic pattern with the absence of pathognomonic clinical signs 2. The activity of glutathione reductase in the blood was low in most patients with cystic Postnecrotic immature pancreas 3. Activity of G-6-PDG, glutathione reductase and glutathione indicators can be used as markers of prognosis of complications of pancreatic pseudocysts, depending on their degree of formation
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2019-20
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri and Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

ankara escort

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

pendik escort

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2019 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version