alexa Prevalence Of Common Pathogenic Bacterial And Fungal Agents In Smear Negative Pulmonary Tuberculosis Patients At Selected Health Facilities Of Addis Ababa, Ethiopia, 2011 | 16425
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

3rd International Conference and Exhibition on Pathology

Teklil Biza Gizaw
Accepted Abstracts: J Clin Exp Pathol
DOI: 10.4172/2161-0681.S1.014
Abstract
Lower respiratory tract infection is an important cause of morbidity and mortality in all age groups. Each year 7 million people die due to direct consequences of acute and chronic respiratory diseases. Infectious lower respiratory disease might be caused by Fungal and bacterial agents. However, in various countries including Ethiopia, individuals who have chronic lower respiratory diseases are mostly suspected as having tuberculosis. Several literatures showed that the prevalence of smear negative pulmonary TB cases was increased in the previous two decades. The mortality rate of smear negative patients was greater than smear positive patients in HIV infected individuals. Objectives: To determine the prevalence of bacterial and fungal agents on smear negative pulmonary tuberculosis registered patients in selected health facilities of Addis Ababa. Materials and Methods: A cross sectional study was conducted from November 2010 to May 2011. A total of 229 smear negative Pulmonary TB registered patients in selected health facilities in Addis Ababa were considered and sputum samples were collected from all of them. Common bacterial and fungal agents were detected using microscope and culture techniques. The finding of study was analyzed using descriptive statistic to determine their prevalence of bacterial and fungal agents, Moreover fisher exact & Chi-square tests were used to see association of agents & diseases. Magnitudes of associations were then measured by Binary regression analysis. Result: Our study has suggests that there was no statistically associated with specific etiology identified in culture except weight loss and shortness of breath for Mycobacterium species. Similarly, chest x-ray features were not associated. Among the 229 study participants, 150 (65.5%) showed microbial infection. Infection with fungi, bacteria and Mycobacterium species were identified in 120 (52.4%), 48 (20.8%) and 31(13.5 %) respectively. Moreover,198 (86.5%) were negative for Mycobacterium species using culture techniques; and out of culture negative Tb cases, 102 (51.5%) and 40 (20.2%) study participants had fungal and bacterial infection respectively. From the isolated genus of fungi and bacteria, Aspergillus species and K.pneumoniae were the most frequent microbes respectively. Out of drugs were used for testing isolates, 59.8% was showed resistance by isolates and 28.2% of drugs were showed sensitive pattern. Conclusion and Recommendation: Weight loss and shortness of breath were significantly associated with culture positive Mycobacterium species. From this study, fungus was the most frequent infection identified in more than 50% of the study participants. Therefore, based on the findings of this study, we recommend applying multiple conventional culture techniques for isolation of bacterial and fungal agents before patients are registered as smear negative TB cases. It can help to identify the true etiological agents of the disease there by improving the diagnosis and treatment.
Biography
Teklil Biza Gizaw is working in Ethiopia Health and Nutrition Research institute as researcher and he is the coordinator of Bacteriology and Mycology research case team in the institute. He completed his graduate program in Clinical laboratory sciences at the age of 31 and published more than 5 original articles related to bacterial disease and drug resistance pattern in local journals. He has plenty of experience on conventional culture and drug sensitivity test. And also he is an executive member of Ethiopian medical laboratory association and providing different microbiology course for medical students.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7