Advances in Crop Science and Technology
Open Access

Abstract

Flavonoids are secondary plant metabolities of the polyphenol family with a diversity of biological functions. Most metal-flavonoid complexes are found to have considerably higher antioxidant effects than free flavonoids. Molecular mechanisms of antioxidant activity of flavonoids increased by metal ions are poorly understood.

In our studies, binding of flavonoids (apigenin, kaempferol and luteolin) with metal ions, and radical scavenging activities of corresponding complexes were investigated in detail. Structural factors, such as coordinate proportions of metal ions and flavonoids and steric orientations affecting activities of metal-flavonoid complexes as antioxidants, are elucidated.

Recent Publications

1. Xu Y, Qian L-L, Yang J, Han R-M, Zhang J-P, Skibsted L H (2018) Kaempferol Binding to Zinc(II), E??cient Radical Scavenging through Increased Phenol Acidity. J. Phys. Chem. B 122: 10108???10117.

2. Liu X-C, Du H-H, Fu L-M, Han R-M, Wang P, Ai X-C, Zhang J-P, Skibsted L H (2018) Integrity of Membrane Structures in Giant Unilamellar Vesicles as Assay for Antioxidants and Prooxidants. Anal. Chem. 90: 2126???2133.

3. Yang J, Xu Y, Liu H-Y, Han R-M, Zhang J-P, Skibsted L H (2017) Genistein Binding to Copper(II)-Solvent Dependence and Effects on Radical Scavenging. Molecules 22: 1757???1771.

4. Pereira J C M, Iretskii A V, Han R-M, Peter C. Ford (2015) Dinitrosyl Iron Complexes with Cysteine. Kinetics Studies of the Formation and Reactions of DNICs in Aqueous Solution. J. Am. Chem. Soc. 137: 328???336.

5. Han R-M, Cheng H, Feng R, Li D-D, Lai W, Zhang J-P, Skibsted L H (2014) ????Carotene As a Lipophilic Scavenger of Nitric Oxide. J. Phys. Chem. B 118: 11659???11666.

Biography

Rui-Min Han, Associate professor in Department of Chemistry, Renmin University of China, Beijing, 100872 Research interest: Antioxidant mechanism and application of phytochemicals and their metal complexes. Speciality: time-resolved dynamics (stopped-flow, laser photolysis).

E-mail: rmhan@ruc.edu.cn