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Resistance To β-lactam In Enterobacteriacae And Non-fermentative Gram-negative Bacilli In Tunisia: An Endless Story | 9219
Journal of Clinical & Experimental Pathology
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In Tunisia, resistance trends have changed greatly over the 14 years (1998-2012). In the center-east region of Tunisia (Sousse,
Monastir and Mahdia), resistance mechanisms were described. Carbapenem resistance in Acinetobacter baumannii is due to
Ambler class D: OXA-97 and OXA-23 enzymes and in second degree to GES-11. In Pseudomonas aeruginosa strains, resistance
to beta-lactams is due essentially to SHV-2a, VIM-2 and hyperproduction of cephalosporinase. It is due also to non enzymatic
mechanisms (loss of outer membrane protein).
In Enterobacteriaceae, resistance concerns essentially extended-spectrum cephalosporins, fluoroquinolones and rarely
carbapenems. The most prevalent enzyme is CTX-M-15. However, other enzymes were described (SHV-12, SHV-2a...).
Resistance to quinolones is related to the spread of plasmid-mediated quinolone resistant determinants: QnrB1, qnrB2, qnrA6
The application of rigorous hygiene regulations and the revision of the politics of antibiotic treatment will be key parameters
allowing to encircle these multi resistant bacteria and to limit their scattering.
Wejdene Mansour is an Assistant Professor of Microbiology in the Higher Institute of Applied Sciences and Technology of Mahdia, Tunisia. She got
his B.Sc. in Biological Science, Master?s Degree in Biotechnology and Immunology applied for Contagious diseases in the Faculty of Pharmacy of
Monastir Tunisia, Doctor?s degree (Ph.D.) in Biological and biotechnological sciences (2008). Currently she is the Head member of the Tunisian
Society of Microbiology and is a researcher member of the LR99ES27 research laboratory in the faculty of Pharmacy of Tunisia. Her researches
focus on resistance mechanism in multidrug resistant bacteria especially in the Gramnegative bacilli responsible of nosocomial infections. She is
also interested in resistant bacteria described in food-producing animals. She has published more than 10 papers in reputed journals and serving
as reviewer for several one.
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