Reach Us +1-947-333-4405


Silencing Of Renal DNaseI Is Associated With Up-regulation Of Tumor Necrosis Factor Receptor-associated Protein 1 (Trap1) During Progression Of Murine And Human Lupus Nephritis | 3110
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Google Scholar citation report
Citations : 1174

Journal of Clinical & Experimental Pathology received 1174 citations as per Google Scholar report

Journal of Clinical & Experimental Pathology peer review process verified at publons
Indexed In
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Open J Gate
  • Genamics JournalSeek
  • JournalTOCs
  • Ulrich's Periodicals Directory
  • RefSeek
  • Hamdard University
  • OCLC- WorldCat
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
Share This Page

Silencing of renal DNaseI is associated with up-regulation of tumor necrosis factor receptor-associated protein 1 (Trap1) during progression of murine and human lupus nephritis

International Conference on Pathology

Ole Petter Rekvig

ScientificTracks Abstracts: J Clin Exp Pathol

DOI: 10.4172/2161-0681.S1.002

We have recently demonstrated that transformation of mild glomerulonephritis into end-stage kidney disease coincides with renal DNaseI shut-down in (NZBxNZW)F1 mice and in human lupus nephritis. Down-regulation of DNaseI results in reduced chromatin fragmentation and deposition of extracellular chromatin complexes in glomerular basement membranes where they appear in complex with IgG antibodies. Two objectives were regarded central in this study. First, we aimed new analyses to obtained insight into protection and repair mechanisms in lupus nephritis. The main focus in this study was to resolve whether inflammation-driving silencing of the renal DNaseI gene expression correlated with increased expression of the anti- apoptotic and survival protein tumor necrosis factor receptor-associated protein 1 (Trap1). Secondly, we aimed to translate results from murine lupus nephritis to human lupus nephritis. Mouse and human mRNA expression levels of DNaseI, and Trap1, were determined and compared with protein expression profiles and clinical data. The data demonstrate that silencing of DNaseI gene expression is highly negatively correlated with increased sessile expression of the Trap1 gene. acquired reduction in DNaseI appears to be important for progression of disease in both the murine and human formsof lupus nephritis.The loss of renal DNaseI seems to initiate a cascade of inflammatory signals leading to the up-regulation of repair proteins like the Trap1.

Ole Petter Rekvig completed his Medical Immunology in 1981 at the University of Troms?. He has served as professor in molecular immunology and pathology from 1984, and has served as consultant at the University Hospital from 2000. He has published scientific papers on molecular pathology and immunology with a special interest in processes linked to lupus nephritis.