alexa
Reach Us +1-947-333-4405
Synaptic Adhesion Like Molecule (SALM4) Regulates Angiogenic Functions Via VEGFR2 Activation | 80938
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Synaptic Adhesion Like Molecule (SALM4) regulates angiogenic functions via VEGFR2 activation

14th Asia Pacific Pathology Congress

Dong Young Kim

Yonsei University, Republic of Korea

Posters & Accepted Abstracts: J Clin Exp Pathol

DOI: 10.4172/2161-0681-C1-041

Abstract
Synaptic Adhesion Like Molecules (SALMs) is the adhesion molecules, highly enriched in nervous system, include five members (SALM 1-5). All SALMs promote neurite outgrowth, while SALM4 uniquely increases the number of primary processes extending from the cell body. However, the property of SALM4 in Endothelial Cell (EC) is still unknown. Here, we discovered that SALM4 mRNA expression was increased during differentiation from Endothelial Progenitor Cell (EPC) to EC. Unlike other SALMs, SALM4 was expressed specifically in EC. To find functions of SALM4, we performed in vitro assays. Wound and chemotactic migration assays showed that knock down of SALM4 attenuates EC migration. Next, we found tube formation was decreased tube length in SALM4 deletion EC. EC Survival was reduced in SALM4 depletion. In mouse organs, SALM4 shows organ specificity, it was mainly expressed brain and kidney. Consistent with this observation, EC recruitment impaired in SALM4 KO mice injected matrigel with VEGF. Aortic sprouting reduced in SALM4 KO mice aorta implanted matrigel. To elucidate the mechanism of SALM4 under VEGF treatment, we analyzed VEGFR2 activation. Silencing SALM4 in EC suppressed phosphorylation of VEGFR2. Moreover, downstream of VEGFR2 signaling was also reduced. These results suggest that SALM4 has a potential role in regulating EC migration via activation of VEGFR2.
Biography

Dong Young Kim is currently pursuing his Doctor’s course in Vascular Biology at Yonsei University, Republic of Korea. He has completed his Bachelor’s degree in Biochemistry at Yonsei University. His research fields are tumor angiogenesis and identifying angiogenic functions of endothelial cell enriched genes in endothelial cells.
 

Top