Taste And Smell Dysfunction In The United States: The Role Of Otolaryngologists | 12397
Otolaryngology: Open Access
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Taste and smell dysfunction are common clinical problems inhibiting quality of life in millions of patients in the U.S. These symptoms
usually relate to chronic disease processes which initiate loss and distortion of taste and smell. These diseases include hormonal,
metabolic, hematological, neurological, trace metal and nutritional processes. Normally these processes provide growth factors to stimulate
stem cells in taste buds and olfactory epithelium. These growth factors are secreted by parotid glands into saliva to generate taste buds and
by serous glands into nasal mucus to generate olfactory epithelium. Stem cells, under the influence of these growth factors, generate taste
bud and olfactory receptors by which taste and smell function normally occurs. Any pathology which inhibits growth factor secretions
causes loss and distortion of taste and smell. Most otolaryngologists consider these symptoms related to oral or nasal pathology but
biochemical inhibition of growth factor secretion is the major culprit. Since otolaryngologists are the major physician group to whom
patients with these symptoms turn for help understanding generation of these symptoms and their correction is critical. However, methods
to accomplish this understanding are not commonly available. We developed systems to assist otolaryngologists to evaluate and treat
patients with these symptoms. These systems involve (1) psychophysical techniques to measure taste and smell function, (2) biochemical
techniques to collect and measure growth factors in saliva and nasal mucus and (3) therapeutic methods to correct these dysfunctions.
Drugs which increase these growth factor secretions have successfully corrected these symptoms in over 50% of patients.
Dr. Robert I. Henkin received his Ph.D. in 1956 and his M.D. in 1959 both from UCLA. After completing residency in Medicine and Neurology he was a research associate at NIH, Bethesda, MD, in 1961, Section Chief in Neuroendocrinology at NIH in 1965, professor of Neurology at Georgetown University Medical Center in 1975 and Director of the Center for Molecular Nutrition and Sensory Disorders in Washington, DC in 1985. He is now Director of The Taste and Smell Clinic, the first private program dedicated to evaluation and treatment of patients with taste and smell dysfunction.
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