ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Google Scholar citation report
Citations : 1437

Journal of Clinical & Experimental Pathology received 1437 citations as per Google Scholar report

Journal of Clinical & Experimental Pathology peer review process verified at publons
Indexed In
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Open J Gate
  • Genamics JournalSeek
  • JournalTOCs
  • Cosmos IF
  • Ulrich's Periodicals Directory
  • RefSeek
  • Directory of Research Journal Indexing (DRJI)
  • Hamdard University
  • EBSCO A-Z
  • OCLC- WorldCat
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
  • ICMJE
  • world cat
  • journal seek genamics
  • j-gate
  • esji (eurasian scientific journal index)
Share This Page

The immunoexpression of glucocorticoid receptors in breast carcinomas, lactational change and normal breast epithelium and its possible role in mammary carcinogenesis

12th International Conference on Pediatric Pathology & Laboratory Medicine

Raja Alyusuf

Salmaniya Medical Complex, Ministry of Health, Bahrain

Keynote: J Clin Exp Pathol

DOI: 10.4172/2161-0681.C1.030

Abstract
Glucocorticoids (GC) are known to play a role in mammary development and differentiation, thus it is of interest to attempt to delineate it��?s immunoexpression across a spectrum of mammary epithelia. This study aims to delineate the distribution pattern of GRs in malignant versus non-malignant epithelium with particular emphasis on lactational change epithelium as its cells are considered the most terminally differentiated mammary cells. Immunohistochemistry (IHC) for glucocorticoid receptors (GR) was performed on archival formalin fixed paraffin embedded tissue blocks of 97 cases comprising 53 invasive carcinomas, 21 cases with lactational change and 23 cases showing normal mammary tissue histology. The results reveal an over-expression of GR receptors in mammary malignant epithelium compared to both the normal and lactational group individually and combined together as a non-malignant group. This is the first study to compare GR expression in human lactating epithelium versus malignant and benign epithelium. GR overexpression was also established in HER-2 negative cancers as compared to HER-2 positive ones, while GR immunoexpression in tumors categorized according to grade, estrogen (ER), progesterone receptor (PR) or axillary lymph node (ALN) status showed no statistical difference. It seems that GR expression in mammary epithelium promotes the development of HER-2 negative breast cancer, thus such receptors may become targets for the development of therapeutic interventions. Further studies are required to determine the level of caution that is needed if any in the use of steroid therapy in such category of patients.
Biography

Raja Alyusuf is a Fellow of Royal College of Pathologists since 1998. She is a Consultant Histopathologist with special interest in the area of Breast Treatment. She chaired the Department of Pathology at Salmaniya Medical Complex for 10 years after which she became the Deputy Chief of Medical Staff for Diagnostic Affairs at the Salmaniya Medical Complex. In addition, she is a part-time Associate Professor of Pathology at the Royal College of Surgeons, Ireland-Bahrain branch. She has over 20 publications is reputable journals and is a member of a number of international and national professional associations.

Email: RYousif@health.gov.bh

Top