Journal of Clinical & Experimental Pathology
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Vascular endothelial growth factor (VEGF) is thought to be an important angiogenic factor that involved in
tumor growth, progression and metastasis.
The present study evaluate the relation between tissue expression, serum and salivary levels of VEGF in head and
neck squamous cell carcinomas (HNSCCs) and their correlation with clinicopathologic features.
Method and Materials:
Samples were collected from 30 patients with HNSCCs and 24 healthy volunteers. Immunohistochemical
analysis was used for tissue expression and ELISA was employed to measure serum and salivary levels.
No VEGF staining was observed in normal tissues; whereas VEGF expression was seen in six patients (20%). Mean
serum level of VEGF was 83.7?104.47 in patients and 50.04?32.94 in controls. Mean salivary level of VEGF was 174.41?115.07
in patients and 149.58?101.88 in controls. No significant difference was found by Mann-Whitney statistical test between
controls and patients (respectively P: 0.411, P: 0.944). No correlation was found between VEGF tissue expression and its serum
and salivary level.
In the present study, over expression of VEGF was found in HNSCC patients that suggest its role in the pathogen
Marziyeh Hamzavi has completed his DDS at the age of 23 years from Zahedan State University and Postdoctoral studies from Shiraz University of Medical
Sciences, School of Dentistry. She has published more than 15 papers and posters in reputed journals and conferences.
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